Effects of Two Excipients to the Disposition of Rifampicin and Diazepam Based on P-glycoprotein

25. June 2012 · Comments Off · Categories: Pharmacy · Tags: , , , , , , , ,

The aim of this study was to investigate the effects of Pluronic(?) F68 and Labrasol on the intestinal absorption and pharmacokinetics of rifampicin in rats, and examine the effects of Pluronic(?) F68 on the plasma and brain concentration of diazepam in mice.Methods1. Wistar rats were divided into eight groups. A bolus dose of perfusion buffer [...]

Effects of Two Excipients to the Disposition of Rifampicin and Diazepam Based on P-glycoprotein

23. June 2012 · Comments Off · Categories: Pharmacy · Tags: , , , , , , , ,

The aim of this study was to investigate the effects of Pluronic(?) F68 and Labrasol on the intestinal absorption and pharmacokinetics of rifampicin in rats, and examine the effects of Pluronic(?) F68 on the plasma and brain concentration of diazepam in mice.Methods1. Wistar rats were divided into eight groups. A bolus dose of perfusion buffer [...]

Effects of Two Excipients to the Disposition of Rifampicin and Diazepam Based on P-glycoprotein

22. June 2012 · Comments Off · Categories: Pharmacy · Tags: , , , , , , , ,

The aim of this study was to investigate the effects of Pluronic(?) F68 and Labrasol on the intestinal absorption and pharmacokinetics of rifampicin in rats, and examine the effects of Pluronic(?) F68 on the plasma and brain concentration of diazepam in mice.Methods1. Wistar rats were divided into eight groups. A bolus dose of perfusion buffer [...]