As one of the most common hematologic malignancies, malignant lymphoma comprises a heterogeneous group which consisting of different clinicopathologic entities. Extranodal NK/T-cell lymphoma is a rare subtype of lymphoma, significantly different from other types of lymphoma, the histological features of this disease are angiodestruction, massive necrosis and apoptosis. Although most of the cases initially present [...]
[Objective] Lung cancer is the first leading cause of cancer-related death in China.Currently, the outcome of resection or chemotherapy for lung cancer is not satisfactory.Individualized treatment according to specific genetic background is very important forimproving outcome. One aim of this study is to investigate the association of singlenucleotide polymorphism (SNP) of a group of important [...]
Background:The aim of this study was to investigate prognostic value of excision repair cross-complementing1(ERCC1), BCL2-associated athanogene (BAG-1), the breast and ovarian cancer susceptibility gene1(BRCA1), ribonucleotide reductase subunit M1(RRM1) and class Ⅲ β-tubulin (TUBB3) in patients with non-small cell lung cancer (NSCLC) who received platinum-based adjuvant chemotherapy.Methods:Messenger RNA expressions of these genes were examined in85tumor tissues [...]
Purpose By immunohistochemical method for the detection of Ⅰ～Ⅲa stage non-small cell lung cancer tissue of patients with drug-resistant gene excision repair cross-complementing group1and Ribonucleotide Reductase M1expression, discuss ERCC1and RRM1expression on the survival prognostic implications, and provide basis for clinical treatment of clinical treatment, implementation of individualized treatment.Method75patients in Ⅰ～Ⅲa NSCLC are detected by using [...]
Background:Currently, a investigation of national resident inquest which released by the the Ministry of Health showed:in China, the malignant tumor is the first death cause of urban residents and it was one of the most serious diseases which are harmful to the health of human beings. The report also showed that the lung cancer caused [...]
ObjectiveThrough the research of different grades of glioma tissue in ERCC1, IDH1and normal brain tissue expression, discussion of the ERCC1and IDH1expression in the relationship of brain glioma, clarify, development and molecular mechanism, in order to further discuss the prognosis of gliomas assessment and chemotherapy regimens, the results may serve as a clinical brain glioma aneurysms [...]
Objective:To investigate the Expression of ERCC1、BRCA1 and the correlation with platinum-based chemotherapy Clinical Efficacy in the advanced non-small cell lung cancer. Materials and Methods:We have retrospectively studied the 152 patients with advanced non-small cell lung cancer from January 2005 to May 2010 using platinum-based chemotherapy as first-line treatment. The tissue was examined by immuno-histochemical stains. [...]
Objective:To investigate the Expression of ERCC1、BRCA1 and the correlation with platinum-based chemotherapy Clinical Efficacy in the advanced non-small cell lung cancer. Materials and Methods:We have retrospectively studied the 152 patients with advanced non-small cell lung cancer from January 2005 to May 2010 using platinum-based chemotherapy as first-line treatment. The tissue was examined by immuno-histochemical stains. [...]
ObjectiveERCC1,XPD protein and mRNA expression level of NSCLC(non-small cell lung cancer)and cancer adjacent tissues were detected to understand the relationship between protein expression and the pathological features of NSCLC. The relationship between the ERCC1 and XPD expression and the survival after platinum-containing chemotherapy was studied through follow-up to provide a theoretical basis for further screening [...]
ObjectiveERCC1,XPD protein and mRNA expression level of NSCLC(non-small cell lung cancer)and cancer adjacent tissues were detected to understand the relationship between protein expression and the pathological features of NSCLC. The relationship between the ERCC1 and XPD expression and the survival after platinum-containing chemotherapy was studied through follow-up to provide a theoretical basis for further screening [...]
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