Objective: To observe the effect of PPAR gamma (peroxisome proliferator activated receptor )agonist pioglitazone pretreatment on myocardial ischemia reperfusion myocardial apoptosis andon the expression of GRP78 and Caspase-12 proteins in rats.so as to explore the the endoplasmicreticulun stress signaling pathways for pioglitazone in protection of m yocardium.Methods: male Wistar rats, the ordinary diet feeding. Weight [...]
Skeletal fluorosis is complex and diverse pathological changes, and itspathogenesis has plagued the medical fiels for many years, a lot of academicdisagreement appears. Recently, it was demonstrtated that high bone turnoverand active osteoblast function play a key role in the occurance and developmentof skeletal fluorosis through in vivo and in vitro experiments. The boneturnover and [...]
Objective1. Explore the effects of aerobic exercise and high fat diet in the lipid metabolism.2. Observe the effects of aerobic exercise and high fat diet in atherosclerosis.3. Explore the effects of aerobic exercise and high fat diet in endoplasmic reticulum stress for liver。MethodsThe research object of the experiment is40male mice BALB/c only eight weeks. Randomly [...]
ObjectiveTo explore the apoptotic effect of ubiquitin-proteasome inhibitor MG-132 on human tongue squamous cell carcinoma cell line Tca-8113 cells through endoplasmic reticulum stress.MethodsTca8113 cells were cultured in RPMI 1640 medium which supplemented with 10% fetal calf serum, the exponential phase cells were divided into 5 groups: negative control group is what the cell culture medium [...]
PrefaceDiabetes is a serious public health problem of common diseases, the current 7 million worldwide,100 million DM patients, DM in the next 25 years will reach 300 million patients with 6 million. DM consists of clinical type 1 diabetes and type 2 diabetes, and T2DM accounted for DM 90% to 95%. T2DM is a skeletal [...]
Acute kidney injury (AKI) is a common clinical syndrome as well as a kind of complication in critically-ill patients, if the AKI develops into severe acute renal failure (ARF), the mortality rate will reach up to 50%, and 10% -14% of patients with acute renal failure need for lifelong renal replacement therapy since the renal [...]
Acute kidney injury (AKI) is a common clinical syndrome as well as a kind of complication in critically-ill patients, if the AKI develops into severe acute renal failure (ARF), the mortality rate will reach up to 50%, and 10% -14% of patients with acute renal failure need for lifelong renal replacement therapy since the renal [...]
Background The endoplasmic reticulum (ER) stress response consists of a set of adaptive pathways that can be triggered by disparate perturbations of normal ER function, such as accumulation of unfolded proteins, lipid or glycolipid imbalances, or changes in the ionic conditions of the ER lumen. The primary purpose of the ER stress is to alleviate [...]
ObjectiveTo comparatively investigate the difference of capsaicin-inducing apoptosis of multi-drug resistant leukemia K562/ADM cells and its parental drug-sensitive K562 cells, and whether the capsaicin-induced apoptosis of drug-sensitive and -resistant leukemia cells occured via endoplasmic reticulum stress-related pathway. Furthermore, the cytototic or apoptotic effect of capsaicin to leukemia stem cells (LSC) was observed.MethodsK562 cells and K562/ADM [...]
ObjectiveThe aim of the article is to investigate the effect and the mechanism of the JNK pathway in hippocampal area ischemic tolerance induced by endoplasmic reticulum stress preconditioning.Methods216 SD rats were randomly divided into sham group(SH), ischemia/reperfusion group(IR), endoplasmic reticulum stress precon ditioning group(IP), IP+IR group(IP+IR), Curcumin+IR group(CU), Curcumin+IP+IR group(CP), Anisomycin+IR group(AN), Anisomycin+IP+IR group(AP) and [...]
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