Gallbladder cacrinoma is a highly malignant gastroenteric tumor with Poor Prognosis anddifficult diagnosis in early stage. So，it has very important clinical significance to find newtnmormarker, to diagnosis、therapy and prognosis of gallbladder cancer.Objective: The experiment to explore the expression of E-cadherin、β-catenin and cyclin D1 ingallbladder carcinoma、gallbladder adenoma and cholecystitis，accoding to the result analysis thecorrection between three [...]
[Objective]To investigate the expression of Fascin protein in ovarian serouscystadenocarcinoma and its correlation with clinical pathological parametersand prognosis. To further explore its mechanism and role in ovariantumorigenesis and progession for improving early diagnosis of aggressivetumours.[Methods]Paraffin sections using tissue microarrays including43case of ovaryserous cystadenocarcinoma,22cases of ovary borderline serous cystadenoma,17cases of Ovary serous cystadenoma and18cases of normal [...]
Background and ObjectiveCurrently, Esophageal carcinoma is one of the common malignant tumor in digestive system that have the characteristics of high incidence and high mortality, in which,the most common is esophageal squamous cell carcinoma, about90%. Each year about300000people die of this disease worldwide, China is a high incidence area of esophageal cancer in the world, [...]
Objective:Effects and mechanism of quercetin on proliferation, apoptosis, Invasion and metastasis of hepatocarcinoma cell line HCCLM6were studied so as to illustrate the anti-tumor mechanism of quercetin, and further theoretical evidence of which as an anti-tumor drug may be provided.Methods:1.HCCLM6cells dealt with different concentrations quercetin (20、40、60、80、100μmol/L) were then analyzed by MTT assay to calculate the cells’survival [...]
Objective To investigate the role of E-cadherin expression and the promoter methylation of E-cadherin gene in the malignant transformation process of hydatidiform mole. To explore the possibility of re-expression of the methylated and silenced E-cadherin gene through DNA methyltransferase inhibitor5-Aza-CdR. Methods SP immunohisto-chemistry technique was performed to search for protein expression of E-cadherin gene in [...]
Objective To investigate the expression of RKIP and E-cadherin and their relationshipwith clinical-pathologic parameters in gastric adenocarcinoma, and to approach the correlationbetween RKIP and E-cadherin.Methods The expression of RKIP and E-cadherin were studied in 60 cases of gastricadenocarcinoma tissues, 30 cases of adjacent noncancerous gastric tissues by immumohisto-chemical technology(SABC). Results were compared with clinical-pathologic parameters, [...]
Objective:To investigate the expression of Twist, E-cadherin and B-catenin and its prognostic significance in thymoma.Methods:We, with immunohistochemical PV-6000 method, detect Twist, E-cadherin and B-catenin in 71 cases of thymoma, and analyze the expression and clinicopathological factors including prognosis in surgical specimens.Results:The positive expression of Twist in group of A,AB,B1,B2,B3 is 20.0% (2/10)、18.8%(3/16)、23.5%(4/17)、18.8%(3/16)、25.0%(3/12), respectively. The positive [...]
Background：Cadherin encoded by E-cadherin gene between the epithelial cells, which mediatehomogeneity adhesion and maintain the tissue structural integrity. E-cadherin is animportant tumor suppressor gene, it can inhibit the proliferation of tumor cells and theinvasion and metastasis of cast-off tumor cells.E-Cad gene inactivation result inreduction of the expression of the protein and prompte the development of [...]
Objective:Observe the expression level of protein with epithelial-mesenchymal transition in human colon cancer cells SW480 in vitro,which were treated by mesenechymal stem cells.Study the regulation effect of MSC on Wnt/β-catentin signaling pathway, and the expression level of target genes (MMP-7, COX-2,β-catentin). The goal is to established the influence and probable mechanism of MSC on human [...]
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