Objective:Malignant tumor seriously disease threaten human health and has become a serious social problem. Doxorubicin is a broad-spectrum anticancer drugwith good effect.Due to its serious side effects, such as cardiac toxicity,its clinical use is limited. Polyethyleneimine (PEI)-DNA-doxorubicin (DOX) complexes can effectively deliver doxorubicin to the target site and reduce its toxicity. In this experiment, we [...]
Objective:To investigate the role of cellular prion protein (PrPc) in breast cancer cells apoptosis.Methods:Using Western-bloting method for protein detection; immune fluorescence method for target protein localization and semi quantitative analysis; retroviral vector RNAi for establishing PrPc knockdown stable cell lines; MTT method for the determination of cell viability and normal cell growth curve; trypan blue [...]
Chapter1:This chapter briefly introduced the properties, structure and the research progress of graphene. The research on pharmacology, toxicology and analytical detection and the electrochemical determination progress of doxorubicin, methotrexate and o-nitrophenol were summarized in this chapter.Chapter2:This chapter mainly introduced the synthesis of β-CD modified graphene （CD-GNs） from graphite and β-CD by wet chemical method. UV, [...]
In this study, two new series of amphiphilic methoxy-poly(ethylene glycol) grafted polyphosphazenes with different hydrophobic side groups including glycine ethyl ester (GlyEt),ethyl 4-aminobenzoate(EAB) and, N,N-diisopropylethylenediamine(DPA) (DPA) were synthesized and characterized. Differential synthesis strategies of amphiphilic graft polyphosphazenes were established to achieve controlled hydrophilic ratio of each copolymer with relatively high product yield. Copolymer structure was [...]
Hydroxyapatite (HAP) is a kind of carrier with good biocompatibility. Controlling its structure and size makes it get a high drug-loading, good release effect and passively targeted performance, which reducing toxic effects of traditional anti-cancer diagnosis and drugs by decreasing the drug dose.HAP particles of different particle size range with the hollow spherical structure were [...]
In aqueous medium, amphipathy polymers could self-assemble into micelles who act as a passive targeted drug delivery system. In this research, dextran was hydrophobic decorated, and then Dex-SA was synthesized. Through varying the molecular weight of dextran and feeding amount of stearic acid, six types of Dex-SAs were synthesized and physicochemical properties were investigated:the chemical [...]
As the increasing number of patients with chronic heart failure, attacksof acute decompensated heart failure and acute heart failure have beenbecoming the main cause of hospitalization in patients with heart failure,and almost two thirds of the patients are caused by ADHF. According tosurveys in our country , the infection is the common inducement of ADHF.While [...]
As the increasing number of patients with chronic heart failure, attacksof acute decompensated heart failure and acute heart failure have beenbecoming the main cause of hospitalization in patients with heart failure,and almost two thirds of the patients are caused by ADHF. According tosurveys in our country , the infection is the common inducement of ADHF.While [...]
Background and objective Renal fibrosis is the common pathway of chronic kidney diseases(CKD) running to end-stage renal disease (ESRD) resulting from various reasons. Glomerular sclerosis and tubulointerstitial fibrosis are known as classical changes of renal fibrosis. The resarch of pathogenesis and dominant factor in early stages renal fibrosis is important to explore the effective means [...]
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