Titanium (Ti) and its alloys are widely used as metallic biomaterials for fabrication of dental and orthopedic implants, owing to their good mechanical, chemical properties, and favorable biocompatibility in a body environment. However, the bioactivity of the titanium alloy is not good enough to form chemical combination to surrounding tissue. In addition, the poor tribological [...]
Titanium alloys are widely used as the implants in the biomedical field owing to their excellent physicochemical propertites and biocompatibility in the human environment. However, due to their bioinert, titanium alloys can not bond with bone firmly. With similar chemical composition and crystallographic structure to that of bone mineral, Hydroxyapatite (HA) can directly bond to [...]
Titanium metal and its alloys have been widely used as dental implants, skeletal repair and orthopedic for their superior mechanical properties and good biocompatibility. However, as bio-inert material, it is difficult to form a strong chemical bonding between titanium and host bone after implantation. In addition, the oxidation film on titanium surface is too thin [...]
This paper provides prerequisite preparation for gene therapy of Collagen gel containing chitosan gene.The method of enzyme digestion was used to extract collagen from bovine tendon so that triple helix of collagen molecules can be maintained. And the extracted collagen was characterized. The extracted collagen viscosity and solid content were measured. In pepsin digest method, [...]
Tissue engineering is a field of research in biomedical engineering that applies the principles of engineering and life sciences to improve tissue biologic function. As an important research field of tissue engineering, biomaterials are widely used in the clinic. Currently, synthetic biomaterials (bioceramics and biopolymers) have been widely applied to the tissue engineering fields. Poly [...]
Mechano growth factor (MGF) is a novel growth factor from the alternative splicing of Insulin-like growth factor I (IGF-I) gene, which is expressed in response to the mechanic stimulation. Further studies have confirmed that MGF and its E peptide (MGF-Ct24E) could promote muscle hypertrophy, preserve cardiac muscle and repair the damage of nerves. Our previous [...]
Congenital malformation and rheumatic heart disease, heart degradation and acquired heart valve disease caused by bacterial infections will lead to heart valve dysfunction, and seriously threat to human life. The last treatment of the disease is the artificial heart valve replacement. Mechanical valves have been widely used in the current artificial heart valve replacement due [...]
Background: Surgical heart valve replacement is an effective way to treat problem valves. Mechanical valve is the most widely used artificial heart valves in the clinical application and has good durability. It is mainly made by some biomaterials such as pyrolytic carbon and Titanium alloy and so on. Patients with mechanical valves require lifelong anticoagulation. [...]
The regenerated Antheraea yamamai/Bombyx mori(A.y/B.m) silk fibroin blend film and porous material were prepared by blending regenerated Antheraea yamamai and Bombyx mori silk fibroin solution.This paper took a research on the relationship between preparation conditions and physic-chemical properties.The cytocompatibility and histocompatibility were also studied.The A.y/B.m blend films were prepared by casting A.y/B.m mixture solution on [...]
In recent years, the unique chemical and mechanical properties of Bombyx mori (B. mori) silk fibroin have made this protein polymer highly attractive for biomedical uses. However, the Antheraea pernyi (A. pernyi) silk fibroin containing the tripeptide sequence Arg-Gly-Asp (RGD), which is known to exhibit specific interactions with mammal cells, has better biocompatibility than B. [...]
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