Aplastic Anemia is diagnosed by the low amount of one marrow hematopoietic stem cell caused by physicochemical,biological,pharmaceutical and other unknown factors,bone marrow hematopoietic function failure caused by the damage of hematopoietic microenvironment,and the pancytopenia(which means lower counts of all three blood cell types:red blood cells,white blood cells,and platelets).This disease harms greatly to patients,and it has [...]
[Objective]To investigate the efficacy and safety of combination of cyclosporine A with stanozolol in children with chronic aplastic anemia(CAA).[Methods]Thirty children patients received combination of cyclosporine A (3mg/Kg/d) and stanozolol (0.14mg/Kg. d)treatment. Twenty-seven/thirteen children were treated and followed at least twelve months. The whole blood routine test, transfusion dependence and bone marrow smears were investigated and [...]
Objective: In the hand injury patients, the tendon injuries accounted for about 30%, tendon defects and need for line of the tendon transplant accounted for 25%. The traditional method of tendon defect is autologous tendon transplantation, which existence shortcomings of drawn limited and influence derived site function and others. Since the 1950s, launched a study [...]
Objective To observe the effect of cyclosporine A on myocardial ischemia-reperfusion injury(MIRI) in rat hearts,and to explore the mecha- nisms of protective effect.Methods Thirty-two SD rats were randomly divided into four groups.Sham group,ischemia-reperfusion group(I/R),CsA group and CsA +5-HD group(n=8).The rats in CsA and CsA+5-HD group were administered cyclosporine A 15mg·kg-1·day-1 by peritoneal injection for 5 [...]
Objective:To explore the anti-fibrotic mechanism of pravastatin and losartan co-treatment in a rat model of chronic cyclosporine A (CsA) nephrotoxicity.Methods:Five subgroups of Sprague-Dawley rats were given vehicle, CsA (15mg/kg s.c), CsA and losartan (10mg/kg in drinking water), CsA and pravastatin (20mg/kg in drinking water), or a combination of CsA, losartan, and pravastatin for 4 weeks. [...]
Objective To observe the effect of cyclosporine A on myocardial ischemia-reperfusion injury(MIRI) in rat hearts,and to explore the mecha- nisms of protective effect.Methods Thirty-two SD rats were randomly divided into four groups.Sham group,ischemia-reperfusion group(I/R),CsA group and CsA +5-HD group(n=8).The rats in CsA and CsA+5-HD group were administered cyclosporine A 15mg·kg-1·day-1 by peritoneal injection for 5 [...]
Objective To observe the effect of cyclosporine A on myocardial ischemia-reperfusion injury(MIRI) in rat hearts,and to explore the mecha- nisms of protective effect.Methods Thirty-two SD rats were randomly divided into four groups.Sham group,ischemia-reperfusion group(I/R),CsA group and CsA +5-HD group(n=8).The rats in CsA and CsA+5-HD group were administered cyclosporine A 15mg·kg-1·day-1 by peritoneal injection for 5 [...]
Objective To observe the effect of cyclosporine A on myocardial ischemia-reperfusion injury(MIRI) in rat hearts,and to explore the mecha- nisms of protective effect.Methods Thirty-two SD rats were randomly divided into four groups.Sham group,ischemia-reperfusion group(I/R),CsA group and CsA +5-HD group(n=8).The rats in CsA and CsA+5-HD group were administered cyclosporine A 15mg·kg-1·day-1 by peritoneal injection for 5 [...]
ObjectiveThe chemotherapeutic treatments represent one of the principal clinical options, and may contribute to inhibiting disease progression and improving overall survival, quality of life for leukemia patients. Unfortunately, the resistance by tumor cells to chemotherapeutic drugs results in the failure of chemotherapy or disease relapse. Multidrug resistance (MDR) means that tumor cells after exposition to [...]
Background and ObjectiveThe ishcemia reperfusion injury is pathological phenomenon, after reperfusion the damage of brain will be worse than before.It is a complex pathophysiological process, including the injury of free radicle, destabilization of intracellular Ca2+, releasing of inflammatory cytokines, activation of apoptosis gene and increased releasing of excita-tory amino acid. In recent years, the role [...]
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