BackgroundGlomerular proteinuria is due to the causes of damage to the glomerular filtration barrier, and glomerular epithelial cells play a key role in maintaining the integrity of the glomerular filtration barrier. Many studies published in past decades revealed that, the mutation of NPHS1, NPHS2, ACTN and Synaptopodin cause congenital renal diseases. The animal models of [...]
BackgroundGlomerular proteinuria is due to the causes of damage to the glomerular filtration barrier, and glomerular epithelial cells play a key role in maintaining the integrity of the glomerular filtration barrier. Many studies published in past decades revealed that, the mutation of NPHS1, NPHS2, ACTN and Synaptopodin cause congenital renal diseases. The animal models of [...]
Background:Proteinuria is not only the common clinical manifestations of glomerular disease, but also the important risk factor of chronic renal failure, hypertension and cardiovascular disease. For a long time, people lack of understanding about the mechanisms of the proteinuria in various glomerular diseases, thus there is short of truly effective treatment clinically. Many molecules have [...]
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