Objective:This research is aimed to optimize the “Zhilou Xunxi Ji” prescription. We designed several animal experiments to reform the medicine amount and dosage of Zhilou Xunxi Ji and so as to provide objective experimental data to demonstrate the basal treatment effect of the adjusted prescription of Zhilou Xunxi Ji. And according to the experimental data, [...]
Multiple post-treatment measurements are often collected more than two times in the clinical trials. And comparing treatment effects in terms of average change from baseline is a very common practice in these clinical trials.The analysis of covariance model (ANCOVA) is commonly used for handling multiple post-treatment measurements comparison. ANCOVA with the baseline values as the [...]
Objective:To evaluate the clinical efficacy and security of HouZaoNiuHuang power in treating acute tracheitis and bronchitis.Method:Select480cases who suffer from acute tracheitis and bronchitis following randomization, blindness, positive parallel control, multi-central method required in the clinical trials. They were randomly divided into two groups, treatment group takes HouZaoNiuHuang power including360cases, control group takes TianHuangNiuHuang power. The [...]
Part1Study of Mutant Prevention of Colistin combined with Levofloxacin against MDR-ABObjective:(1) To acquire MICs of ten antibiotics against MDR Acinetobacter baumannii isolated in recent years;(2) To select and class bacterial genotypes by PFGE;(3) Based on the theory of MSW, MPCs was to be measured and analysed of the strains;(4) To set up a method to [...]
Objective:To study the effect of Lamivudine combing with Double Tigers and Yi GanYiQiJieYu Powder in treating chronic hepatitis B and to assess the clinic effectiveness of Tradiional Chinese Medidne.Methods:All of the 120 chronic hepatitis B cases were divided into two groups randomly. Every group has 60 cases. The treatment group was treated with Lamivudine Combined [...]
Objective:To study the effect of Lamivudine combing with Double Tigers and Yi GanYiQiJieYu Powder in treating chronic hepatitis B and to assess the clinic effectiveness of Tradiional Chinese Medidne.Methods:All of the 120 chronic hepatitis B cases were divided into two groups randomly. Every group has 60 cases. The treatment group was treated with Lamivudine Combined [...]
Objective:To observe the effect of matrine injection on the lung mesenchymal fibrosis patient’s quality of life clinical smptoms and inflammatory factor.Methods:60 patients with lung mesenchymal fibrosisi were divided into two groups at random:the treatment group and the control group. The treatment group was given matrine injection,small amount of glucocorticoid and symptomatic treatment.The control group was [...]
The estimates of treatment effect, individual variation and adverse reaction are always inaccurate at the beginning of a clinical trial. In an adaptive design, investigatos need to perform interim analysis in the mid-term of the trial based on acquired data. The subsequent trial may be adjusted according to the result of interim analysis.Conditional power （CPower） [...]
Object①To investigate the safety and efficiency of a new percutaneous kyphoplasty surgical instrument with high viscosity bone cement.②To observe the clinical outcome of the osteoporosis thoracolumbar compression fractures. Methods1. 19 patients with osteoporosis thoracolumbar compression fractures were included (4 male and 15 female, age range 53-80 years old, average age 69.63±8.39 years old). 24 osteoporosis [...]
Part one:Clinical trial of reversing drug resistance of glioma stem cellsObjective: ABCG2, a drug resistance gene, is proved to be only expressed on glioma stem cells. Our study has proved that nicardipine can reverse the drug resistance of ABCG2 both in vitro and in vivo. Here we try to verify it in one clinical study.Methods: [...]
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