Objective:To screen the BSEP gene in intrahepatic cholestasis of idiopathic infantile hepatitis patients. And investigate the relationship between intrahepatic cholestasis of idiopathic infantile hepatitis and bile salt export pump gene.Methods:A total of115cases of idiopathic infantile hepatitis with intrahepatic cholestasis in case group and60idiopathic infantile hepatitis persons who had no intrahepatic cholestasis in the control group [...]
Objective: To detect the expression and location of Bsep and Mrp2 after hepatic ischemia-reperfusion: experiment with rats,and to investigate the mechanism of hyperbilirubinemia after rat hepatic ischemia-reperfusion.Methods: Sixty healthy MaleSprague-Dawley(S-D) rats were randomly divided into 2 groups(thirty ras in each group):Group A(the control group),rats were not subjected to hepatic ischemia reperfusion.Group B,rats were subjected to [...]
Objective Based on the mice model of rifampicin (RIF) -induced liver injury, we detect the molecule mechanism of rifampicin-induced intrahepatic cholestasis. Methods To observe liver injury induced by is rifampicin in mice, eighty females mice were randomly divided into 4 group: Rifampicin (RIF) 1w group and RIF 6 h group: Cholestasis was induced by administration [...]
Objecfive:Malignant obstructive jaundice is a common disease clinically, and when diagnose, most of the patients have lost the opportunity of operative eradication, operation. PTBD/PTBS have become one of the main therapeutic method of malignant obstructive jaundice which has lost operative opportunity. They have certain curative effect, small trauma and liess complication. This study aim at [...]
Objective To analyze the Perinatal prognosis of children in early-onset Intrahepatic Cholestasis of Pregnancy, and to provide the referential evidences for Screening and treatment of ICP patient of early.Methods From 1999 to 2010 in women’s hospital of zhejiang university, get 100 cases of early onset Intrahepatic Cholestasis of Pregnancy(gestational weeks less than 32 weeks). At [...]
Liver injury is a common disease which is caused by HBV and/or HCV infection、alcohol、drugs and other causes. Because liver injury may progress into cirrhosis or liver cancer, it remains a serious threaten to human health. Liver injury is reversible, so early diagnosis and correct assessment of liver injury are very important. MicroRNAs(miRNAs) are a family [...]
Hepatic fibrosis is a wound-healing process responsive to a variety of factors,which involves the abnormal accumulation of collagen, degeneration and necrosis of hepatocytes, and damages to liver architecture and function. It has been proved by clinical research and experimental work on animals that hepatic fibrosis is the key process in the conversion of chronic liver [...]
OBJECTIVE: To compare the effect and investigate the mechanism of potent farnesoid X receptor （FXR） ligand-chenodeoxycholic acid（CDCA） with ursodeoxycholic acid（UDCA） on metabolism of bile acid in rats with estrogen-induced intrahepatic cholestasis of pregnancy（ICP）.METHOD: We set up ICP rat model with Estradiol Benzoate(EB,2.5 mg·kg-1·d-1). Then CDCA(100 mg·kg-1 daily) or UDCA(50 mg·kg-1 daily) was administrated to the [...]
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