Objective To explore the effect of Nuodikang capsule on learning and memory and activities of AchE and ChAT in hippocampus tissue of Alzheimer’s disease(AD) animal model.Methods 32 rats were randomly divided into four groups as following,8 rats in each group: Aβ1-40 micro-injection group(model group), Aβ1-40 micro-injectiond and Aricept Tablets given group(Aricept Tablets group),Aβ1-40 micro-injectiond and [...]
Objective To explore the effect of Nuodikang capsule on learning and memory and activities of AchE and ChAT in hippocampus tissue of Alzheimer’s disease(AD) animal model.Methods 32 rats were randomly divided into four groups as following,8 rats in each group: Aβ1-40 micro-injection group(model group), Aβ1-40 micro-injectiond and Aricept Tablets given group(Aricept Tablets group),Aβ1-40 micro-injectiond and [...]
Objective: To explore the effects of perinatal malnutrtition on AchE and ChAT of hippocampus in the male rat offspring in the 21days after birth. So that to study the effect of perinatal malnutrition on the onset of dementia.Methods: Eight Sprague-Dawley rats,with 14 days’pregnant, were purchased and housed individually. And randomly divided the rats into two [...]
Alzheimer’s disease (AD) is a progressive cognitive impairment and memory-based central nervous system damage degeneration, its pathogenesis is very complex and large number of foreign study found that exercise training can promote AD animal model of pathological learning and memory improvement and improved. The large number of animal studies have proved that appropriate training can [...]
Background:Ageing of the population is an important problem which is the present society pays close attention to.Postoperative cognitive dysfunction is a subtle disorder of thought processes that may influence isolated domains of cognition such as verbal memory,visual memory,language comprehension,visuospatial abstraction,attention,or concentration.POCD seriously affects quality of life of the aging.It can lead to delay of rehabilitation [...]
ObjectiveTo investigate FOS、CHAT and VIP expression in the medullary visceral zone of the rats following cerebral hemorrhage(CH)complieated with multiple organ dysfunotion syndrome(MODS);TO discuss the potential role of vagus never and its transmittance CHAT、VIP in CMODS.Methods1.Model of Cerebral hemorrhage complicated with MODS was induced in rats by injecting CoilagenaseⅦinto the caudase putamen.Subdiaphragmatic vagotomy or vagus nerve [...]
Objective To investigate the influences on performances of behaviors, and capability of learning and memory in offspring of rats in late gestation of being exposed to different concentrations of sevoflurane for 6 hours.Methods 15 SD rats at gestational ages of 18 days were randomly divided into 3 groups, namely high concentration of sevoflurane group (group [...]
Objective: To observe the therapeutical effect of JiannaoYizhi decoction in vascular dementia model rats induced by chronic ischemia and investigate its partial mechanism. Methods: This study choose healthy male Wistar rats of 3-5 months, the rats were randomly divided into sham-operated group, model group, Donepezil group and JiannaoYizhi decoction high, medium and low dose group.The [...]
Implications and objectiveStudies demonstrate lasting cognitive impairment in elderly persons after anesthesia such as isoflurane and surgery; it can be summarize into post-operative delirium (PD) and postoperative cognitive dysfunction (POCD). PD usually occurs 1～3 days after surgery and anesthesia ,and persist for several hours to several days or even weeks; while POCD generally happens one [...]
ObjectivesTo observe the changes of acetylcholine metabolism of hippocampal of depression models on rats and the impact of Chaihu Shugan Powder on it. To further explore the function of the cholinergic nervous system to the occurrence and development of depression and the antidepressant mechanism of Chaihu Powder.Methods60 male Sprague-Dawley rats of 4～5 month old from [...]
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