Objective To investigate the effects of recombinant human granulocyte colony-stimulating factor(rhG-CSF) on the expression of nuclear factor-kappaB(NF-ΚB) and induciable nitricoxide synthase(iNOS) in rats with focal cerebral ischemia/reperfusion. To explore the anti-inflammatory mechanisms of rhG-CSF, and to provide a new theoretical basis for clinical application.Methods Thirty-six male Sprague-Dawley rats were randomly divided into the sham-operated group, [...]
The restoration of blood flow after ischemia can also cause further tissue demage anddysfunction in some cases which we called it reperfusion injury.ObjectiveTo establish the cerebral ischemia reperfusion injury model of rats. To observe the effects ofEtomidate postconditioning on the brain tissue malondialdehyde(MDA)concentration andsuperoxide dismutase(SOD)activity in rats induced by cerebral ischemia-reperfusion(CIR) so asto investigate cerebral [...]
ObjectiveTo study the effect of indomethacin preconditioning to the content of IL-1β and CRP in brain tissue in rats after focal cerebral ischemia reperfusion.MethodsEighty-four healthy male SD rats were randomly divided into three groups: sham-operation group, model group and indomethacin preconditioning group, there are twenty-eight rats in each group. The middle cerebral artery occlusion(MCAO) model [...]
Objective Although,many studies have found that exercise training can promote the restoration of functions of patients with cerebral infarction,the study of training intensity has become more and more important.How long the rehabilitation therapy period should be to gain the best results for functional restoration and whether the intensive training(increase recovery time)can improve clinical outcomes haven’t [...]
Background and ObjectivesStroke is one of the three fatal diseases, which has the “three high” characteristics of high incidence,high morbidity and high mortality.lt could seriously affect people’s quality of life and bring heavy burdens to their families and countries. Stroke is divided into ischemic stroke and hemorrhagic stroke, Ischemic stroke accounts for more than80%of stroke, [...]
Objective: To observe the effect of MTT-treatment and Propranolol-treatment on the histologicoutcome，apoptosis at different time points on the model of focal cerebral ischemia-reperfusioninjury in rats，To investigate the expression of Bax、Bcl-2 and NGF in the model of focalcerebral ischemia-reperfusion and the neuroprotective effect of MTT-treatment andPropranolol-treatment，To explore the neuroprotective mechanism ofβ-adrenergic receptorblockers in the model of [...]
Objective To investigate effect of sevoflurane postconditioning on neuronal apoptosis aftercerebral ischemia-reperfusion injury in rats and the role of PI3K/Akt signaling pathway inwhich.Methods Forty male SD rats which were from Shanxi medical university animal experimentcenter with250-270g body-weight were randomly divided into five groups(with8rats each): Cgroup,ischemia-reperfusion(IR group),2.5%sevoflurane postconditioning group(S group),2.5%sevoflurane+LY294002group (S+LY group) and DMSO group． The [...]
PartⅠEFFET OF IFENPRODIL ON SURVIVIN EXPRESSION AFTER CEREBRAL ISCHEMIA REPERFUSIONObjective:To investigate the expression discipline of survivin after perifocal area of cerebral after ischemia-reperfusion (I/R) in rats, and to identify the effect of ifenprodil on Survivin after I/R. Method:Seventy-two Wistar rats were randomly divided into three groups:shame group, model group and ifenprodil group. The middle cerebral [...]
PartⅠEFFET OF IFENPRODIL ON SURVIVIN EXPRESSION AFTER CEREBRAL ISCHEMIA REPERFUSIONObjective:To investigate the expression discipline of survivin after perifocal area of cerebral after ischemia-reperfusion (I/R) in rats, and to identify the effect of ifenprodil on Survivin after I/R. Method:Seventy-two Wistar rats were randomly divided into three groups:shame group, model group and ifenprodil group. The middle cerebral [...]
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