ObjectiveIt is generally believed that the heart becomes a postmitotic and differentiated organ,atwhich point the cardiomyocytes withdraw from the cell cycle.Recenly,scientists have provedthat myocardial cells could reenter into the cell cycle on the condition of physiology andpathology.The cell signal mechanism of ischemic post-conditioning(IPO)to ischemicreperfusion injury,not only inhibits cell apoptotic,but slso regulates the cell cycle.The IPOprotect [...]
[Objectives] To compare the flavonoids content of Allium cepa extracted from water and ethanol, and the influence of the extractions on colorectal cancer cell proliferation、apoptosis and cycle.[Method] Allium cepa was extracted by water and ethanol, the flavonoids content of the extractions were detected by UV. Colorectal cancer cells(Lovo cells、SW480cells、HT-29cells、 HCT-8cells) were cultured in vitro, the [...]
Objective To establish the approach of isolation, purification and culture of testicular Leydig cells in rats, and to explore the toxic effect of Leydig cells and its mechanism induced by nickel sulfate at different exposure concentration and time in vitro.Methods (1) Leydig cells were isolated and purified respectively by using collagenase dispersion, the density gradient [...]
Objective:To explore The effects of BuyangHuanwu Decoction on the signal transduction of NF-κB factorn and cell proliferation on rats following focal cerebral ischemia to provide proof for clinic to facilitate work.Methods:Rat model of cerebral ischemia injury was created by the middle cerebral artery occlusion (MCAO) with suture method, healthy adult SD rats were randomly divided [...]
Object ivesIn the present research, we aim at:1. Evaluating the effect of atractylodes macrocephala on the proliferation of normal IEC-6cells and DFMO-induced growth inhibitory IEC-6cells;2. Evaluating the effect of atractylodes macrocephala combined with licorice on the proliferation of DFMO-treated IEC-6cells;3. Examining p21and p53mRNA and protein expression after administered atractylodes macrocephala alone or combined with licorice [...]
Radix Paeoniae Alba (RPA) and Radix Paeoniae Rubra (RPR) are commonly used as traditional Chinese herbal medicines. It is specified in China Pharmacopoeia (2010version) that RPR originates from wild Paeonia lactiflora Pall. and Paeonia veitchii Lynch., and RPA originates from cultivar of Paeonia lactiflora Pall. After being decorticated and boiled, the roots are usually dried [...]
Objective：To explore the effect of quercetin and17-DMAG which were usedsolely and together on Radiosensitization of human uterine cervix cancer cell line(HeLa)in chemical hypoxia induced by CoCl2, and reseach of the possible mechanism. Cellswith different conceration of quercetin and17-DMAG which were used solely andtogether,the expression of HIF-1αand HSP70protein was detected by Western-Blotting;The effects of quercetin and17-DMAG [...]
Objective： Deinococcus radiodurans (DR）is one of the microorganisms whichexhibits an extraordinary ability to withstand the lethal and mutagenic effects ofionizing radiation, ultraviolet radiation, strong oxidizer and chemical mutagen. It is oneof the most radioresistance life-forms which have been found so far. Research has so farproved inconclusive about the specific mechanism for this super resistant. A [...]
In the world, cancer Incidence and mortality rates showed an increasing trend. Cancerhas become the “killer” following the cardiovascular disease, which is a serious hazard tohuman health. Currently, the primary means for tumor treatment are surgery, chemotherapy,radiotherapy, biological therapy, endocrine therapy, Chinese medicine treatment,hyperthermia and radiofrequency ablation therapy and so on. As the tumor traditionaltreatment [...]
The Influence of Fluid Shear Stess on Osteoblastic Cells Proliferation Through ERK5Signaling Pathway
[Object] This study explore to the involvement of ERK5signaling pathway in the proliferation response of osteoblastic cells to fluid shear stress, to provide the basis to establish the transmission mechanism of mechanical stress in the bone tissue.[Methods] Fluid shear stress on cultured osteoblastic cells exert the same intensity at different times with EKR5inhibitor, MTT assay [...]
Hello,My name is Jack,Ph.D. Supervisor, Welcome to My WebSite