Objective: To observe the effect of PPAR gamma (peroxisome proliferator activated receptor )agonist pioglitazone pretreatment on myocardial ischemia reperfusion myocardial apoptosis andon the expression of GRP78 and Caspase-12 proteins in rats.so as to explore the the endoplasmicreticulun stress signaling pathways for pioglitazone in protection of m yocardium.Methods: male Wistar rats, the ordinary diet feeding. Weight [...]
BackgroundRheumatoid arthritis(RA) is a kind of autoimmune disease which can cause disability highly.70%of the patients have joint erosion, of whom about90%occured in the first2years. About14%of patients stop working in the fist12months. In recent10years, the biggest progress in RA field has been early diagnosis and early combination therapy, which is vital for reducing bone damage and [...]
Objectives1.Observe the influence of midkine (MK) to ventricular remodeling in rats with acute myocardial infarction (AMI);2. Study the influence of midkine (MK) to P-ERK1expression, to further explore the mechanism of MK to ventricular remodeling.MethodsForty-eight adult male Wistar rats were randomly divided into four groups:Control group(n=6), Sham-operated group(n=6), infarct model group (AMI group,n=18), MK treatment group [...]
Background:Recently some reports have confirmed single utilization of bone marrow mesenchymal stemcells in rat traumatic brain injury can enhance the recovery of the function and reduce theapoptosis in the injury area,but the effect is not obvious,it may be short of efficient vascularendorsement;vascular endothelia growth factor also can accelerate the reconstruction of thevascular in the injury [...]
[Objectives] To compare the flavonoids content of Allium cepa extracted from water and ethanol, and the influence of the extractions on colorectal cancer cell proliferation、apoptosis and cycle.[Method] Allium cepa was extracted by water and ethanol, the flavonoids content of the extractions were detected by UV. Colorectal cancer cells(Lovo cells、SW480cells、HT-29cells、 HCT-8cells) were cultured in vitro, the [...]
ObjectiveThis paper aims to explore the expressing rules and mutual relationship between CaMKⅡδand apoptosis gene bcl-2bax in the issue of myocardial hypertrophy, and to make clear the regulation mechanism of CaMK Ⅱδ in cell apoptosis, which works for providing a new approach to develop new drugs in clinical research and development to prevent myocardial hypertrophy [...]
Objective This study was aimed to explore the effects of emodin on proliferation inhibition and apoptosis induction in human acute myeloid leukemia cell line KG-la cells, and to investigate the effects of Bcl-2/Bax gene.Methods KG-la cells were exposed with emodin at different concentrations. The growth inhibition was measured by MTT method. The change of cell [...]
Objective:By detecting the expression of caspase-3 and caspase-7 in CA3 area of the hippocampus and the cortex of the post-status epilepticus of temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat. Discussion if there are the apoptosis neurons in the hippocampus of the post-status epilepticus of temporal lobe epilepsy induced by electrical [...]
Objective:Observe the effect of acupuncture Du meridian people, Bai Hui, the Ren Zhong, the Da Zhui of Resistance to injury and protection of the ischemic area. Observed ischemic brain tissue TNF-α and Caspase-3expression to explore acupuncture Du meridian people, Bai Hui, the Ren Zhong, the Da Zhui on the brain to produce the protective effect [...]
Recently reported that it is an affinity between Ⅱ type diabetes mellitus and atherosclerosis，butinflammation maybe considered a common pathological mechanism. As we know，Sphingomyelin is anindependent risk factor for atherosclerosis，therefore we infer Sphingomyelin maybe related to2typediabetes mellitus. More, Ceramide is considered as regulating signal factory in cell apoptosis andproliferation.Furthmore, Sphingomyelin and Ceramide are important chemical compround [...]
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