Background and ObjectiveEsophageal cancer (EC) is one of the six most commom malignant tumors, which is ranked as the fourth frequent cause of cancer-related death in China and the sixth in the world. Esophageal carcinoma is characterized by its significant regional differences, mainly concentrated on the Taihang mountain area, and the incidence of EC from [...]
Background and Objectas the standpoint that long-term chronic cerebral hypo perfusion can lead to kinds of neurodegenerative diseases be confirmed by a great quantity of experimental data, people begin to focus on the chronic cerebral hypo perfusion more and more frequently. chronic cerebral hypo perfusion keep close contact with cognitive deficiencies of aging people and [...]
Objective:To investigate whether miR-206 could regulate Cdc42 protein expression and cytoskeleton remodeling.Methods:miR-206 was transfected into MDA-MB-231 cells using LipofectamineTM 2000, after 48h cells were harvested. Western blot was used to detect proteins expression, Actin-Tracker Green was used to stain F-actin and filopodia was observed under fluorescent microscope. Invasion Assay and Migration Assay were taken to [...]
Objective:Peripheral lymphocytes adhere to the endothelium and infiltrate into infarcted tissue after acute ischemic stroke. Cdc42, a small GTPase, is responsible for mediating adhesion and migration of lymphocytes. It is known that Golgi apparatus is involved in the metabolism of Cdc42. Little is known about the changes of Cdc42 expression on peripheral lymphocytes after acute [...]
Study on the Signaling Transduction Mechanism of Smooth Muscle Cell Migration Induced by Rho GTPases
Background:Intimal hyperplasia is the principal cause of restenosis of blood vessels following vascular intervention or injury. Migration from the media to intima and subsequent proliferation of vascular smooth muscle cells(VSMC) are key events in the early development of the intimal hyperplastic lesion. Thus the actin-based structures which have tight relation with the migration of VSMC [...]
The X-linked lymphoproliferative disease is an inherited severe or fatal immune dysfunction generally triggered by infection with Epstein-Barr virus. Boys with XLP often develop a lethal fulminant infectious mononucleosis following EBV infection. Some patients also develop progressive dysgammaglobulinemia or aggressive lymphoproliferative disorders, such as malignant lymphomas. Less commonly, the XLP patients may also develop autoimmunity, [...]
INTRODUCTIONThe oocyte maturation process is controlled by many signal pathways, which play critical roles for the ongoing of GV and GVBD as well as polar body formation.Along side with meiosis of Xenopus oocyte,one pole of metaphaseⅠspindle attaching the cortex spatial and temporally,trigger onset of downstream events,such as furrow locolization,contractile ring formation,cytokinesis and polar body emission. [...]
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