Colorectal cancer (CRC) is one of the most common malignancies and leading causes of cancer death. However, the drugs available now remain not yet satisfied because of their shortcomings. Hence, it is still meaningful to develop the new anti-tumor drugs. Therefore, the present study is aimed to demonstrate the anti-tumor activity of caffeic acid 3,4-dihydroxy-phenethyl [...]
Objective:To explore the Rock2 regulatory mechanism on cell cycle protein Cdc25A and to study the growth effect in hepatoma carcinoma cells.Methods:After transfection of Rock2-siRNA into hepatoma carcinoma Huh-7 and HepG2 cells, flow cytometer and MTT assay were used to observe the changes of cell cycle and cell growth. In response to UV induced DNA damage, [...]
Objectives:To explore the protein expression of CDC25A, CDC25B(from the cell division cycle 25-CDC25) and TGF-β1, with regard to their interactions and clinical significance in indicating non-Hodgkin’s lymphoma(NHL) staging and subtype, expecting to provide a guide for the diagnosis, treatment, and prognosis of NHLMethods:30 pathologically and immunohistochemicaly diagnosed NHL patients were collected at the Third Xiangya [...]
Objective The Xeroderma Pigmentosum D(XPD)gene plays an important function in DNA repair path ,because it is a key factor of DNA nucleotide excision repair-dependent signaling. Research shows that when the XPD gene mutations in the gene ,a higher susceptibility to tumor. This project studied that the XPD gene represses hepatoma carcinoma cell(HCC). To investigate the [...]
Objective: This study was designed to investigate the proliferation inhibition, apoptotic induction and to explore the mechanism in human ovarian cancer SKOV3 cells treated by Cpd 5 to provide experimental data for clinical application of Cpd 5 as an novel anticancer drug for human ovarian cancer. Methods: SKOV3 cells were cultured regularly and divided into [...]
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