Objective: Explore the role of nutritional obesity,which effects on adolescent malerats testicular germ cell apoptosis pathway of Fas / Fas-L system.Method: Select 24, animal rating of SPF Wistar healthy male rats which age are of 3weeks , randomizedly divided into two groups, namely the control and experimentalgroups, each group have 12 rats. Control mice fed [...]
ObjectiveTo explore the influence of Dihydroartemisin on the activity of Caspase-3and the growth of human ovarian cancer cell line HO-8910transplanted tumor under the skin of nude mice.MethodTo establish the subcutaneously transplanted tumor of human ovarian carcinoma in nude mice and then the mice were randomly divided into low-dose-group of Dihydroartemisin, high-dose-group of Dihydroartemisin, saline group, [...]
Objective: Neonatal Hypoxic-Ischemic Brain Damage (HIBD) caused in most cases by perinatalasphyxia. It appeared a series of clinical encephalopathy and was one of the important causes inchildren with disability in China. This experiment set up neonatal rat hypoxic-ischemic braindamage (HIBD) model, to observe the expression of HIF-1αof brain tissue after neonatal ratswith HIBD and possible [...]
Objective To investigate the expression of PCNA, Caspase-3 and Bcl-2 in glomerulus ofdifferent pathological type of IgA nephropathy (IgAN), and preliminary discuss the significanceof the expression of Caspase-3 and Bcl-2 in different type of IgAN. Analyzes the relationshipbetween clinical index and PCNA, Caspase-3, Bcl-2. Further to offer the theory supports aboutapoptosis of the different pathological [...]
ObjectiveTo investigate the effects of topical use of licorice flavonoids on photoaging mice skin which is induced by medium-wave ultraviolet B (UVB) irradiation, and its impact on stress related regulatory molecules in the endoplasmic reticulum, and discuss the intervention effect of licorice flavonoids on photoaging mouse skin induced by UVB radiation, find out the possible [...]
Objective:To investigate neuroprotective of dl-3n-butylphthalide on focal cerebral ischemia reperfusion injury in rats and study the mechanisms of it by analyzing the correlation between Caspase-3and PDCD-5.Methord:Two hundred and eight healthy male Wistar rats were chosen to establish cerebral ischemia reperfusion model with middle cerebral artery thread embolism methord and were randomly divided into the sham [...]
Objective: The aim of this study was to investigate the mechanism of lenalidomideon the growth of human hepatoma cell line SMMC-7721cells in vitro growth and tocompare of curative effect with thalidomide.Methods: SMMC-7721cells were treated with lenalidomide or thalidomide atdifferent concentrations. CCK-8assay was used to assesse the cell growth inhibition andcompare the differences between them for [...]
Background:Vitexicarpin is one of the flavonoid components extracted from Vitex rotundifolia, many studies have reported that it can inhibit proliferation of kinds of tumor cells,however, the effect of vitexicarpin on pituitary adenoma cell has not been reported. Objectives:To investigate the anti-proliferration effect on pituitary GH3cells and explore the molecular mechanism. Methods:We evaluate the proliferation of [...]
BackgroundOsteosarcoma is a common malignancy in clinical accounts for about20%of primary bone tumors. Because of the high degree of malignancy of osteosarcoma, the rapid rate of progress and the characteristics of vulnerable to relapse and metastasis, its Treatment is very poor. Although Osteosarcoma of the jaw accounted for5%of the oral and maxillofacial malignancies, with the [...]
OBJECTIVE1.To investigate the pathological formation process of diabetic cornealkeratopathy by confocal microscopy in vivo diabetic rabbit model.2.To analyse thepathogenesis of diabetic keratopathy in the level of biological overall,we combine thevivo confocal microscopy observations and hematoxylin-eosin staining of diabeticrabbit corneal tissue sections.3.To study the relationship between the apoptosis ofcornal cell and the expression of caspase-3and the [...]
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