Objective Neural tube defects is one of the most common birth defects, which comprises a series of defects such as anencephalia, encephalocoele, myeloschisis and so on. The development and differentiation of neural tube is a very complicated biological process. This process is regulated and affected by various teratogens, and one notable environmental teratogen is fetal [...]
Objective Gliomas are the most common type of intracranial tumors, which account for about 50% of all the primary brain tumors.Because of their infiltrating and scalable growth,the tumor tissues often have no clear border with surrounding normal brain tissues.So surgery is hard to eradicate the tumor.What’s more,the glioma cells are not sensitive to traditional radiotherapy [...]
Objective To investigate the inhibition effects of SPG on mice hepatoma by giving different doses of SPG in H22 cell, and discussed the mechanism from caspase-3 and bax protein expression in hepatoma cells, proliferation of hepatoma cells, serum levels of TNF-a, tumor weight and body weight aspects.Methods Fifty mice were inoculated with hepatoma H22 cells [...]
Part IExpression of Caspase-4 and Caspase-3 Gene Related Apoptosis in Sternocleidomastoid of Congenital Muscular Torticollis Shenzhen Children’s Hospital, Zunyi Medical College Wang Shuaiyin (Candidate of MD) Tang Shengping (Supervisor)Objeetive To detected protein expression of Caspase-4 and cleaved Caspase-3 in sternocleidomastoid of congenital muscular torticollis and to explore the possible mechanism of apoptosis in the pathogenesis [...]
Objective To study the relationship of action of matrine on mouse fibroblasts L929 cells and eIF4E、caspase-3 mechanisms.Methods The L929 cells were treated by different concentration of matrine. the concentration were as follow:0.25g/L,0.50g/L.0.75g/L,1.00 g/L. The viability of L929 cells were measured by MTT assay. Expression of phospho-eIF4E, phospho-eIF4E-BP 1 and caspase-3 were determined by Western blot [...]
On the basis of stable and reliable fluid percussing traumatic brain injury(TBI) models, we studied the therapeutic effects of Yunnan Baiyao on the model rats by testing Neurological Severity Score(NSS),cerebral edema, apoptosis index and related Caspase-3 gene expression.Part One:The foundation of moderate or severe TBI model and the effect of Yunnan Baiyao on NSS and [...]
Background and Objective:Imbalance of apoptosis has a closely relationship with the occurrence and development of tumors. Ovarian tumors are common tumors of female genital mutilation, who died of ovarian cancer, accounts for various types of gynecological cancer first, a serious threat to the life of women. XIAP is a known inhibitor of apoptosis protein family [...]
Objectives:1. To isolate and purify the antimicrobial peptides from the Musca domestica larvae withinhibition activity to K562 cells in chronic myelocytic leukemia, and to observe whether damagethe normal-human cells 293T (human renal epithelial cells).2. To observation the influence of the antimicrobial peptides purified to the K562 cellviability and the growth curve and to observation the [...]
Objective:Investigate the changes on the expressions of FasL and caspase-3 in soleus muscle of damage side after transplantation of microencapsulated rabbit sciatic nerve cells/tissue treating spinal cord injury(SCI) in adult Sprague-Dawley (SD) rats. And the possible mechanism of the rehabilitation induced by the transplantation of the microencapsulated xeno-sciatic nerve cells/tissue treated SCI were discussed.Methods:The rabbit [...]
Objective:Established the animal model of transection lesion of spinal cord,in order to observe the effect of body weight support treadmill training (BWSTT) and electric acupuncture in changing the GAP-43 and Caspase-3 in the spinal cord, and study the primary mechanism on the transection lesion of Spinal Cord.It will provide the theory evidence for the experimentally [...]
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