Objective To observe the effect of candesartan on structural remodeling and electrical remodeling of left heart in hypertension patients with paroxysmal atrial fibrillation.Methods One hundred hypertension patients with paroxysmal atrial fibrillation were enrolled and divided randomly into the treatment group(n=50) and control group(n=50). The patients in treatment group took candesartan4mg per day arally and the [...]
Objects:By establishing rat non-alcoholiefattyliverdisease(NAFLD)model with high-fat diet to observe the effects of Candesartan on liver function in Atherosclerosis rats. This experiment will provide a referenee for clinical drug treatment.Methods:Fifty male SD rats were randomly divided into normal group,Atherosclerosis model group,low,medium and high dose group of Candesartan。Normal group were fed on normal diet. Atherosclerosis model group [...]
ObjectiveTo observe the effect of angiotensinⅡreceptor 1 blocker candesartan on diabetic retinopathy in different time rats and investigate its mechanism.Methods85 male SD rats were obtained. 16 rats were obtained by random as normal control group (NC group). The diabetic rat model was built by tail vein injection of streptozotocin. Except 5 died or not successful [...]
Objective: The present study observed the kidney and retina expression of the vascular endothelial growth factor (VEGF) and connective tissue growth factor (CTGF) in streptozotocin-induced diabetic rats and the intervention effects of candesartan to examine the role of VEGF and CTGF in the development in the early stage of diabetic nephropathy and retinopathy,and the mechanism [...]
Objective: The present study observed the kidney and retina expression of the vascular endothelial growth factor (VEGF) and connective tissue growth factor (CTGF) in streptozotocin-induced diabetic rats and the intervention effects of candesartan to examine the role of VEGF and CTGF in the development in the early stage of diabetic nephropathy and retinopathy,and the mechanism [...]
Objects:By establishing rat non-alcoholiefattyliverdisease(NAFLD)model with high-fat diet to observe the effects of Candesartan on liver function in Atherosclerosis rats. This experiment will provide a referenee for clinical drug treatment.Methods:Fifty male SD rats were randomly divided into normal group,Atherosclerosis model group,low,medium and high dose group of Candesartan。Normal group were fed on normal diet. Atherosclerosis model group [...]
ObjectiveTo observe the effect of angiotensinⅡreceptor 1 blocker candesartan on diabetic retinopathy in different time rats and investigate its mechanism.Methods85 male SD rats were obtained. 16 rats were obtained by random as normal control group (NC group). The diabetic rat model was built by tail vein injection of streptozotocin. Except 5 died or not successful [...]
ObjectiveTo observe the effect of angiotensinⅡreceptor 1 blocker candesartan on diabetic retinopathy in different time rats and investigate its mechanism.Methods85 male SD rats were obtained. 16 rats were obtained by random as normal control group (NC group). The diabetic rat model was built by tail vein injection of streptozotocin. Except 5 died or not successful [...]
Objective: The present study observed the kidney and retina expression of the vascular endothelial growth factor (VEGF) and connective tissue growth factor (CTGF) in streptozotocin-induced diabetic rats and the intervention effects of candesartan to examine the role of VEGF and CTGF in the development in the early stage of diabetic nephropathy and retinopathy,and the mechanism [...]
Objective: The present study observed the kidney and retina expression of the vascular endothelial growth factor (VEGF) and connective tissue growth factor (CTGF) in streptozotocin-induced diabetic rats and the intervention effects of candesartan to examine the role of VEGF and CTGF in the development in the early stage of diabetic nephropathy and retinopathy,and the mechanism [...]
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