Objectives: It now appears that vascular calcification is a consequence of pathophysiology processes that precipitation of hydroxyapatite crystals in the vascular wall arises from high calcium/phosphate products and dysregulated locally or systemically of the normal balance between promotion and inhibition of calcification .Calcification may occur at several sites in the cardiovascular system, including the intima [...]
Objective To observe the effect of cyclosporine A on myocardial ischemia-reperfusion injury(MIRI) in rat hearts,and to explore the mecha- nisms of protective effect.Methods Thirty-two SD rats were randomly divided into four groups.Sham group,ischemia-reperfusion group(I/R),CsA group and CsA +5-HD group(n=8).The rats in CsA and CsA+5-HD group were administered cyclosporine A 15mg·kg-1·day-1 by peritoneal injection for 5 [...]
Objective To observe the effect of cyclosporine A on myocardial ischemia-reperfusion injury(MIRI) in rat hearts,and to explore the mecha- nisms of protective effect.Methods Thirty-two SD rats were randomly divided into four groups.Sham group,ischemia-reperfusion group(I/R),CsA group and CsA +5-HD group(n=8).The rats in CsA and CsA+5-HD group were administered cyclosporine A 15mg·kg-1·day-1 by peritoneal injection for 5 [...]
Objective To observe the effect of cyclosporine A on myocardial ischemia-reperfusion injury(MIRI) in rat hearts,and to explore the mecha- nisms of protective effect.Methods Thirty-two SD rats were randomly divided into four groups.Sham group,ischemia-reperfusion group(I/R),CsA group and CsA +5-HD group(n=8).The rats in CsA and CsA+5-HD group were administered cyclosporine A 15mg·kg-1·day-1 by peritoneal injection for 5 [...]
Objective To observe the effect of cyclosporine A on myocardial ischemia-reperfusion injury(MIRI) in rat hearts,and to explore the mecha- nisms of protective effect.Methods Thirty-two SD rats were randomly divided into four groups.Sham group,ischemia-reperfusion group(I/R),CsA group and CsA +5-HD group(n=8).The rats in CsA and CsA+5-HD group were administered cyclosporine A 15mg·kg-1·day-1 by peritoneal injection for 5 [...]
OBJECTIVE: To investigate the mechanism of pharmacology of Smilax china L.,optimize the extraction method and solution for the extraction of Smilax china L. and study the constituents of Smilax china L..METHODS: Using the coliform bacterium to manufacture rat’s chronic pelvic inflammatory disease (CPID) model.Determine the change of IL-2 level in blood serum by using enzyme [...]
The ventilator is one of the most necessary rescue equipments in hospital,and the important tool can lengthen the life and strive for the precious time for the further treatment. In the decade, the modern ventilator developed quickly with the research of machinery ventilated technologies, with the application of new technologies and the improvement of clinic [...]
Objective:To explore the therapeutical effect of Tetramethylpyrazine and Dan-ShenRoot on Chronic allograft nephropathy of rat , reveal the relationship with CAN , then discovering mechanism of action that delaying the proceeding of CAN of rat,which provide a new way of therapy to extend survival time of transplanting kidney.Methods:1.We used Fisher rats as donors and Lewis [...]
Identifying factors that are predictive of allograft loss is the first step to prolonging kidney allograft survival.Graft biopsy is an important way to diagnose allograft diseases,but in China biopsy in transplantation kidneys is not well acceptted already.We therefore choose kidney transplantation recipents who had graft biopsies before in Huashan hospital,study whether acute or chronic pathological [...]
ObjectiveThrough gestation and lactation,iodine deficient or hypothyroid dam rats were administered either an iodine-deficient diet or PTU-added drinking water.We have tested whether congenital iodine deficiency and hypothyroidism could regulate expression of CaMKⅡ,CAM,CaN in pup Cerebellum cortex.To figure out the mechanism that iodine deficiency and hypothyroidism impair functional lesion in pup Cerebellum.MethodsFemale Wistar rats（n=28） aging 2 [...]
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