Background:Periodontal disease, trauma and dental caries caused by tooth loss, and inconvenience to patients with chewing function [1]. Preparation of hydroxyapatite coating in the surface of the implant titanium have been attention, but the HA-coated existence of the degradation and flaking will result in the loss of stability of the implant-bone interface, affecting the long-term [...]
Biomineralization is an important process in tissue formation. The tissue formed underthe regulation of organic substrate possesses a hierarchical structure, the properties of whichare much better than synthetic materials. Hence, it is of great importance to explore theregulation mechanism of organic substrate on the formation of inorganic minerals.In this study, the biomimetic mineralization of calcium [...]
Objective:To evaluate the characteristics of a novel injectable and degradable vertebral bone cement consisting of different content of calcium phosphate and calcium sulfate dihydrate powers ,and select one suitable mixture in order to satisfy the need of application in vertebra minimally invasive operation .Methods:1. The setting time(initial setting time TI and final setting time TF),setting [...]
It has been wildy investigated using Calcium Phosphate Cements（CPCs） as Drug Delivery System. In particular, CPCs can be prepared without the high temperature process, which provide the possibility to use CPCs as delivery systems for some growth factors or some drugs in orthopaedic to improve the concrescence of bone fraction. It is well known that [...]
Recently,a novel sol-gel technique which uses calcium nitrate tetrahydrate and phosphoric pentoxide as Ca and P precursors has been developed to prepare nano HA powder.Compared with other sol-gel processes, it is a simple way which does not require controlling pH value and long time. However,the reaction mechanism of this sol-gel process has not known.In this [...]
Objective Prepare nanophase artificial bone composite scaffold basing on bionics theory,and probe into how different content ratio between collagen and inorganic part as well as different molecular weight of conglutinant agent influence microstructure and property of the scaffold.Method Lead calcic inorganic molecules to deposite onto self-assembled collagen template during coprecipitation under certain reactive condition such [...]
Objective:To compare the efficacy of infection controlling and osseous healing of three bone graft substitutes(BGS) loading vancomycin and explore the characteristics of the three available BGS through in vitro and in vive.Methods:The experiment was divided into three parts.1.The establishment of chronic osteomyelitis modelFifty-four healthy adult New Zealand white rabbits were selected in the experiment,local inoculation [...]
Part I Apoptotic action mechanism and cytotoxicity of oligomeric poly(styrene-co-acrylonitrile) modified montmorilloniteTo evaluate the cytotoxic effect and the mechanism of the apoptotic action of oligomeric poly (styrene-co-acrylonitrile)-modified montmorillonite (PSAN-MMT), the present study is focused on the involvement of anti-proliferation, LDH release, apoptosis level, caspase-3 activity, transcriptional activity of apoptosis-related gene, and apoptosis-related protein and mRNA [...]
Background:In recent years, as the rate of high-energy trauma injury caused by serious traffic accidents injuries, work and high-falling is increasing dramatically, the rate of serious open fracture dislocation and soft tissue is increasing significantly. Infection caused by wound contamination and bacteria residue is a big issue in clinical orthopedics. It is urgent for us [...]
Study on Synthesis and Activation of Calcium Phosphate Bioceramic Powders by Using Shock Wave Method
Calcium phosphate (CP) biomaterials such as hydroxyapatite (HA) and tricalcium phosphate (TCP) has been studied widely by scholars and is a kind of appreciative biomedical materials used for bone prostheses by clinic doctors because it is similar to bones and teeth in inorganic compositions, has good biocompatibility and can bring chemical bonding with bone. Calcium [...]
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