BACKGROUND: An accelerated speed of fracture-healing in patients with traumatic brain injury (TBI) is often encountered in our clinical practice. However the mechanisms responsible for this phenomenon are remain unclear. After TBI, many cytokines or peptides has been reported change their expressions, suggest that the phenomenon of accelerated speed of fracture-healing may be associated with […]

Objective: To investigate the Xinjiang Uygur and Han plasma levels of calcitonin gene-related peptide and cerebral infarction (CI) of the relationship. Methods: The ELISA method, the Xinjiang region of 126 cases of ischemic stroke patients and 108 patients with associated age, gender matched controls plasma calcitonin gene-related peptide (CGRP) levels. Cerebral infarction and one Uighur […]

BACKGROUNDDespite the progress that has been made in bone regeneration, fracture caused by trauma infection and a variety of reasons and Bone nonunion still represent the Medical and socioeconomic challenge.In order to improve the treatment outcome fundamentally, clarify the pathophysiology and molecular mechanisms of bone formation reconstruction and remodeling are the base and starting point. […]

Mas-related G protein-coupled receptors (Mrg receptor) is uniquely located in the small diameter neurons in dorsal root ganglia (DRG) and trigeminal ganglia (TG), suggesting that these receptors are involved in nociceptive information processing or opioid analgesia. Previous studies in our laboratory have demonstrated that activation of rMrgC modulates the development of morphine tolerance.The present study […]

Objectives Through the establishment of selective cut of sensory/motor nerve in rats with tibia fracture as animal model, to study the influence of sensory/motor nerve injury during fracture healing and to detect the influence of calcitonin gene-related peptide (CGRP) on osteoprotegerin (OPG)/osteoclast differentiation factor (RANKL) system during fracture healing process, a preliminary study of peripheral […]

[Objective] Established the rat alveolar bone injured models of the oral immediately implant bed preparation , which aim was to observe the characteristics of calcitonin gene related peptide expression in the alveolar bone healing process by HE and immunohistochemistry assay. We discussed the experession of calcitonin gene-related peptidein alveolar bone healings and remodeling , and […]

BACKGROUNDHypertension is a common disease that impacts human Health. It may cause tissue injury such as heart, kidney, brain and artery. Cardiovascular remodeling is the most important adaptation response. Cardiac remodeling includes cardiomyocyte hypertrophy, apoptosis and myocardial fibrosis, which may cause cardiac functional decompensation and ultimately results in heart failure. Vascular remodeling is structure and […]

Objective:observe the changes of plasma content of endothelin and calcitonin gene-related peptide in embolization of intracranial aneurysms under intravenous anesthesia and the influence of continuous infusion Nimotong on endothelin and calcitonin gene-related peptide.Methods:32 patients undering selective embolization of intracranial aneurysms were randomly divided into two groups, nimotong group (N) and control group (C).After anesthesia induction, […]

Objective:The main purpose of this research was discussing the effects on Calcitonin Gene-related Peptide(CGRP) in the pathogenesis of psoriasis vulgaris preliminarily, by detecting the expression of CGRP in the lesions and CGRP, Anandamide(AEA), Nerve Growth Factor(NGF) in the plasma of psoriasis vulgaris patients. In addition, the changes of the migrating and adhesive ability, along with […]

Objective: To investigate the effects of hepatocyte growth factor(HGF) and calcitonin generelated peptide(CGRP) on childhood inguinal hernia.Methods: Levels of serum HGF and CGRP were measured by ELISA in 60 male childrenwith the inguinal hernia (experimental group 1)and 30 male healthy children (control group 1);The densities of HGF receptor and CGRP receptor on 60 hernia sacs […]