Objetive: This study aimed to detect the prevalence of virulence genotypes of Helicobacter pylori (Hp) in Qing-Dao, China and to investigate the correlation between virulence genotypes and gastric cancer.Methods:52isolates of Hp were cultured from gastric biopsies obtained from31patients with chronic gastritis and21with gastric cancer. The virulence genes, cagA, iceAl, vac A s, i and m [...]
Objective:To construct the recombinant plasmid of protein cagA (cytotoxin-associated gene A) and VacA (Vacuolating cytotoxin A)of Helicobacter pylori and to express the fusion protein in E. coli, for the purpose of detection of wild pathogenic species and patients infected with Hp.Methods:The NCTC11639 strains of H. pylori were collected, DNA were extracted,and the gene segments were [...]
Objective:To construct the recombinant plasmid of protein cagA (cytotoxin-associated gene A) and VacA (Vacuolating cytotoxin A)of Helicobacter pylori and to express the fusion protein in E. coli, for the purpose of detection of wild pathogenic species and patients infected with Hp.Methods:The NCTC11639 strains of H. pylori were collected, DNA were extracted,and the gene segments were [...]
Objective:1.To study the infection of cagA(+)strain of Helicobacter pylori,the expression of P73 protein in gastric antral carcinoma,gastric antral ulcer and chronic atrophic antral gastritis.2.To investigate the relationship between the targets above and the gastric carcinoma.3.To study the infection rate of cagA(+) strain of Helicobacter pylori in different types of Epigastralgia in Chinese medicine.Methods:1.The objects were [...]
PrefaceGastric carcinoma is the fourth most common cancer the scond cause of cancer-related deaths worldwid,with approximately 700,000 deaths worldwide each year.The epidemiological studies have indicated that Helicobacter pylori plays a key role in the developments of gastric carcinomas.H.pylori is a gram-negative, spiral-shaped bacteium.It is seperated and cultured by Warren and Marshall in 1984. Based on [...]
Helicobacter pylori（H.pylori） is the main pathogenic factor of chronic gastritis, peptic ulcer and gastric cancer.Patients with serious gastric diseases are usually infected by H.pylori containing cag PAI,Cytotoxin-associated protein A（CagA） coded by cagA participates in a series of signal transductions in host cells and results in inflammatory damage of tissues even canceration on different levels.Patients in [...]
Objective:1.To investigate the antimicrobial agents resistant status of Helicobacter pylori (Hp) isolated from patients suffered with upper gastrointestinal diseases to five common medicines (amoxicillin, clarithromycin, metronidazole, levofloxacin, furaltadon) and the relationship between the antimicrobial agents resistance and the diseases in Lanzhou area. It will be provided as a guideline for choosing effective agents to eradicate [...]
Helicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with the development of peptic ulcer diseases, atrophic gastritis, and gastric malignancies. Epidemiological studies on large series show that Helicobacter pylori is a group I carcinogen for gastric carcinoma,which is one of the most frequent cancers worldwide.Helicobacter pylori is a gram [...]
AIMS (1) To investigate the diversity of vacA and cagA of Helicobacter pylon (Hp) from patients from Guangzhou city or around area, and analyze characteristic of genotype distribution of H. Pylon strains and the relationship between the genotype and pathogenesis. (2) To establish mouse model infected with Hp and Helicobacter heilmanii (Hh). (3) To develop [...]
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