Objectives:To establish the steady model of hepatopulmonary syndrome and study the pathogenesis,at last we will know the clinical symptom and find the clinic medicine to defend the illness.Methods:The model is established in the Wistar rats by bile duct ligation.The rats are divided into two groups, one group is given the operation, the other is not [...]
Objectives:To establish the steady model of hepatopulmonary syndrome and study the pathogenesis,at last we will know the clinical symptom and find the clinic medicine to defend the illness.Methods:The model is established in the Wistar rats by bile duct ligation.The rats are divided into two groups, one group is given the operation, the other is not [...]
ObjectiveBile duct ligation (BDL) leads to complete biliary obstruction and obstructive jaundice (OJ), causing complete blockage of cholesterol excretion and then hyperlipidemia develops. Fibrates are usually used for the treatment of dyslipidemia, which moderate high level of triglyceride (TG) and cholesterol significantly. Therefore, we infer that fenofibrate may play a good role in liver injury [...]
ObjectiveBiliary atresia(BA)is a severe neonatal hepato-disease involving external and intrahepatic bile duct in infancy which results in liver cirrhosis in the end.The feature of BA remains progressive inflammation,obstruction,fibrosis of the biliary system, then disappeared in the end.Hepatic fibrosis procession will still to be progress, even though reconstruction operation was administrated.About 80%of patients will need liver [...]
Fibrosis is a wound-healing response that engages a range of cell types and mediators to encapsulate injury. Although the mechanisms is very complex,liver becomes hypoxic may be the main promotion factors in during early stages of this desease.AimTo study the role of hypoxia in BDL induced hepatic fibrosis in rats.Methods1.BDL or sham-operations were performed, and [...]
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