Pathologic myopia (PM), or high myopia, degenerative myopia, is defined as a spherical equivalent refractive error of at least-6.0dioptres(D), an axial length>26mm, accompanied with degenerative changes of the retina, choroid and sclera at the posterior segment. The fundus abnormalities include lacquer cracks, Fuch’s spot, chorioretinal atrophy, choroidal neovascularization (CNV) and so forth. CNV is an [...]
BackgroundCorneal transparency is based on banlance of low levels of vascular endothelial growth factor and high levels of anti-vascular endothelial growth factor,but corneal inflammation and chemical burn will break the steady-state, resulting in pathological corneal neovascularization [1]. Not only seriously affect vision, but also corneal allograft rejection occurred in high-risk factors after transplantation. On the [...]
Central exudative chorioretinopathy (CEC) is an isolated disease which usually occurs in macula, and causes repeated hemorrhage, exudation, edema, and eventually forms fibrous scar which causes inreversible impairment in macula retinal tissue and permanent impairment of central vision. It is a hang-up in clinical treatment and it is concerned by ophthalmologists for a long time. [...]
Central exudative chorioretinopathy (CEC) is an isolated disease which usually occurs in macula, and causes repeated hemorrhage, exudation, edema, and eventually forms fibrous scar which causes inreversible impairment in macula retinal tissue and permanent impairment of central vision. It is a hang-up in clinical treatment and it is concerned by ophthalmologists for a long time. [...]
Central exudative chorioretinopathy (CEC) is an isolated disease which usually occurs in macula, and causes repeated hemorrhage, exudation, edema, and eventually forms fibrous scar which causes inreversible impairment in macula retinal tissue and permanent impairment of central vision. It is a hang-up in clinical treatment and it is concerned by ophthalmologists for a long time. [...]
Background:Diabetic retinopathy (DR) and diabetic macular edema (DME) are the most common microvascular complications of DM, which may cause visual acuity (VA) declined sharply and even blindness. DME is one of the common manifestations of DR and the main reason of impired VA in DR patients. It is characterized by swelling of the central part [...]
Background:Diabetic retinopathy (DR) and diabetic macular edema (DME) are the most common microvascular complications of DM, which may cause visual acuity (VA) declined sharply and even blindness. DME is one of the common manifestations of DR and the main reason of impired VA in DR patients. It is characterized by swelling of the central part [...]
Objective: Bevacizumab (Avastin,Genentech/Roche ) is a synthetic monoclonal antibody against vascular endothelial growth factor with the molecular weight of 149 kd, indirectly blocking VEGF and its receptors to inhibit the binding angiogenesis, thus inhibiting the formation of new blood vessels and reducing the vascular permeability. Bevacizumab is a very effective drug in sever ocular diseases, [...]
Objective:Investigating the pharmacokinetics and distributions of bevacizumab by intravitreal injection of prepared bevacizumab-PLGA microspheres in order to appraise the safety and prospect of this kind of bevacizumab sustained release dosage form,and to provide evidences for clinical application of it.Methods:Fifteen healthy New Zealand albino-rabbits were used in this study. The eyes of each rabbit received an [...]
Objective: To evaluate the clinical effect of intravitreal bevacizumab combined with triamcinolone acetonide in patients with diabetic macular edema (DME).Methods: Thirty-two eyes with DME inpatients or outpatients in our hospital from August 2009 to September 2010 were randomly divided in to Combination injection group of 18 cases with 20 eyes and single injection group of [...]
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