Objective To investigate the effects of Ligustrazine on denervated skeletal muscle cellapoptosis and expression of bcl-2, bax effect, looking for delaying atrophy of denervated skeletalmuscle in new ways.Methods 54 SPF grade healthy Wistar rats, 3-4 weeks of age, body mass (200±10) g, eithermale or female, were randomly divided into 9 groups: normal control group, respectively [...]
Objective Establish rat70%hepatic ischemia-reperfusion model, injecting propofol to postconditioning on the model, observe the change of histomorphology,the expression of Bc1-2and Bax protein and the apoptosis index (AI) of hepatic cells, and investigate the effects of propofol postconditioning intervention on the ischemia reperfusion injury (IR) in rat livers.Methods Sixty Wistar rats,weighting200-250g,were randomly divided into5groups(n=12):(1)sham operation group(Group [...]
Objective To investigate the expression of PCNA, Caspase-3 and Bcl-2 in glomerulus ofdifferent pathological type of IgA nephropathy (IgAN), and preliminary discuss the significanceof the expression of Caspase-3 and Bcl-2 in different type of IgAN. Analyzes the relationshipbetween clinical index and PCNA, Caspase-3, Bcl-2. Further to offer the theory supports aboutapoptosis of the different pathological [...]
ObjectiveThis paper aims to explore the expressing rules and mutual relationship between CaMKⅡδand apoptosis gene bcl-2bax in the issue of myocardial hypertrophy, and to make clear the regulation mechanism of CaMK Ⅱδ in cell apoptosis, which works for providing a new approach to develop new drugs in clinical research and development to prevent myocardial hypertrophy [...]
Objective Endometrial cancer is one of the most common female cancers, and it seriously endangers the health of women. So Study on the therapeutic approaches and treatment mechanism of endometrial cancer is of great significance. Currently, chemotherapy is an important adjunctive treatment of endometrial cancer, carboplatin is one of the effective chemotherapy drugs. In this [...]
Objective: To investigate the effect of histone deacetylase inhibitor on cellproliferation and apoptosis of human colon cancer cell line HT-29,also to explore itspossible mechanisms of anti-cancer effects.Methods:(1)Human colon cancer cell line HT-29wre treated with differentconcentrations(100,200,400,800,100nmol/L) of histone deacetylase inhibitor (TSA) fordifferent durations(24,48and72h). Cell proliferation was detected by methyl thiazolyltetrazolium(MTT) assay.(2)Cell cycle and apoptosis were assessed [...]
Objective This study was aimed to explore the effects of emodin on proliferation inhibition and apoptosis induction in human acute myeloid leukemia cell line KG-la cells, and to investigate the effects of Bcl-2/Bax gene.Methods KG-la cells were exposed with emodin at different concentrations. The growth inhibition was measured by MTT method. The change of cell [...]
Purpose: Through testing in normal cervical tissue, cervical intraepithelial neoplasia(CIN) and in different stages and different pathological types of cervical carcinoma, theexpression of Fhit protein in cervical cancer and the expression of Bcl-2and Bax, analysis ofFhit protein expression and cervical cancer pathological types, clinical stage, histologicaldifferentiation degree, with no lymph node metastasis in relation to [...]
Background:Vitexicarpin is one of the flavonoid components extracted from Vitex rotundifolia, many studies have reported that it can inhibit proliferation of kinds of tumor cells,however, the effect of vitexicarpin on pituitary adenoma cell has not been reported. Objectives:To investigate the anti-proliferration effect on pituitary GH3cells and explore the molecular mechanism. Methods:We evaluate the proliferation of [...]
BackgroundOsteosarcoma is a common malignancy in clinical accounts for about20%of primary bone tumors. Because of the high degree of malignancy of osteosarcoma, the rapid rate of progress and the characteristics of vulnerable to relapse and metastasis, its Treatment is very poor. Although Osteosarcoma of the jaw accounted for5%of the oral and maxillofacial malignancies, with the [...]
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