Objective:Summarize the clinical manifestation,pathogen distribution,drug sensitive test and bacterial drug resistance of neonatal bacterial pneumonia,and analyze the correlation between the emergence of ESBLs positive bacteria and use of antibiotics especially third-generation cephalosporins,in order to provide a clinical basis for the diagnosis and therapy of neonatal bacterial pneumonia.Methods:Retrospective analyze 140 cases of neonatal bacterial pneumonia cases [...]
OBJECTIVESTo investigate the correlation of trough concentrations（Cmin）/MIC or plateau concentrations（Css）/MIC and clinical efficacy of vancomycin with continuous infusion in patients with bacterial pneumonia and evaluate vancomycin-associated nephrotoxicity while vancomycin serum trough concentration exceeding 10mg·L-1.METHODS1 Determination of plasma vancomycin concentration by RP-HPLCInternal standard was norvancomycin.0.35 mL of 10%perchloric acid was added to 1.0 ml of plasma [...]
Objective:To investigate influence of DUSUQING (DSQ) of Traditional Chinese Medicine Presciptions on JAK/STAT signal transduction pathway in the lung tissue of bacterial pneumonia rat models with phlegm-heat syndrome and to reveal the mechanism of DSQ in treating bacterial pneumonia with phlegm-heat syndrome.Methods:Wistar rats were randomly divided into normal group,pneumonia group,pneumonia with phlegm-heat syndrome group,positive control [...]
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