Objective To investigate the effect and mechanism of pretreatment with atorvastatin，pioglitazone，atorvastatin plus pioglitazone on myocardial ischemia reperfusion injury in ratsmodel.Methods 54 male wister rats were randomly divided into shame-operated group （n=6,normal saline 2ml/d）, I/R group （n=12, normal saline 2 ml/d）, atorvastatin group (n=12, atorvastatin 20mg kg-1d-1),pioglitazone group (n=12,pioglitazone 3mg kg-1d-1) and atorvastati+pioglitazone group (n=12, atorvastatin20mg [...]
Objective:To investigate atorvastatin, pioglitazone and two drugs in combination on ischemia-reperfusion myocardial protective effects and the possible mechanism.Methods:The experimental animals were divided into A, B two groups:healthy male SD rats weighing (200±30) g, were randomly divided into A and B, the two groups.Group A was normal control group, without any treatment.Group B for the diabetic [...]
Objective:The present study was designed to investigate the protective effect ofatorvastatin on contrast-induced acute kidney injury(CI-AKI) in rats，and to explorethe protection mechanisms of atorvastatin on contrast-induced acute kidney injury inrats.Methods:(1)Sixty SD rats were randomly divided into five groups,including normalcontrol group(NS group),contrast media control group(CM group),small doseatorvastatin group(SDA group),high dose atorvastatin group(HDA group),load dosageatorvastatin group(LDA group):rats [...]
Study on Effects of Atorva Statin on Level of IL-17、IL-10and Organ Function in Mid-Grade Septic Rats
Objective：To explore the intervention effect of atorvastatin on mid-grade sepsis bydetecting the expression of IL-17、IL-10in peripheral blood and the expression ofIL-17in liver and kidney tissues of mid-grade septic rats.Method：1、Eighty healthy male S-D(Sprague-Dawley) rats of clean grade wererandomly divided into four groups: the normal group(A),the sham-operated group(B),the mid-grade sepsis group(C)and the Atorvastatin treatment group(D). Rats in [...]
The number of patients with atherosclerosis (AS) is rising quickly, which imply hugeburden on the society and family. Atherosclerotic associated disease is the most commoncause of mortality and morbidity of patients in developing and developed countries. Thestability of carotid atherosclerotic plaques determines the risk of plaque rupture, whichmay lead to thrombus formation and potentially severe [...]
1ObjectiveTo study the content of collagen fibre in myocardial tissue and assess diastolicand systo1ic ventricular function of the rabbits with type2diabetes, evaluate theeffect of atorvastatin in myocardial fibrosis in rabbit model with diabetes mellitus.2Methods22male New Zealand white rabitts were randomly divided into threegroups:normal group(n=6),DMgroup(n=8), atorvastatin group (n=8), atorvastatin5mg/kg/d,TG, TC, GLU,BUN,Cr contents in the serum were [...]
BackgroundAtherosclerosis is due to the blood fat deposition in the carotid endometrial causes the growth of smooth muscle cells, the connective tissue proliferation,the focal intimal fibrous thickening and the formation of atherosclerotic plaque, and eventually causes harden artery walls and luminal stenosis. Lots of researches show that atherosclerosis contributes to couples of cardiovascular diseases such [...]
Background and purposeMyocardial ischemia is one of the leading causes of morbidity and mortality in humans in Western world. In China, the incidence and prevalence of this disease is also increasing year by year. Myocardial revascularization has been an established mainstay in the treatment of CAD for almost half a century. Coronary artery bypass grafting [...]
Objective:The purpose of this study is to evaluation and comparison the lipid levels and cIMT changes of simvastatin, atorvastatin and rosuvastatin in patients after coronary artery interventional treatment.Methods:121patients after percutaneous coronary intervention were randomly divided into three groups, on the basis of standard treatment respectively takeing simvastatin40mg, atorvastatin20mg and Rosuvastatin lOmg everyday. All patients in [...]
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