Objective To observe the alteration of the levels of Ca2+-binding protein S100A12and explore its correlation with coronary artery diseaseMethods125patients were devided into four groups according to clinicalmanifestation and the results of coronary angiography:18patients with stable anginapectoris（SAP group）,37patients with unstable angina pectoris（UAP group）,36patientswith acute myocardial infarction（AMI group）,34patients with normal coronary arteries orminor coronary disease（diameter stenosis,<50%）.The serum [...]
Background and Objective Researches have shown that Peroxisome Proliferaer Activated receptory(PPAR-y) agonists such as thiazolidnediones(TZDs)has the anti-atherosclerotic role in addition to improve insulin resistance, reduce blood sugar. This study aim to comparison the effect of rosiglitazone and simvastatin on the serum levels of IL-18, the expression of MMP-9and MCP-1in aortic atherosclerotic plaques of atherosclerotic rabbits [...]
Background and Objective Studies have shown that peroxisome proliferator-activated receptor gamma (PPAR-y) play an important role in the control of metabolism, inflammation and thrombosis. Recent study found that PPAR-y agonists such as thiazolidnediones (TZDs) play the role of protecting the cardiovascular and slow atherosclerosis duration through its anti-inflammatory and anti-oxidative stress effects, but its mechanism [...]
Background and Objective Thiazolidnediones (TZDs) as peroxisome proliferator-activated receptor-y agonists are widely used for the treatment of type2diabetes. Researches found that the rosiglitazone has the effect of resist to atherosclerosis whether in diabetes or nondiabetes patients. We aim to observe the effects of rosiglitazone and simvastatin to the atherosclerotic plaque formation and on the expression [...]
Rheumatoid arthritis (RA), which main pathological changes are chronic,progressive arthromeningitis and vasculitis, is a chronic, systematic andinflammatory autoimmune disease mainly involving around joints. Theprevalence rate of RA which has high morbidity and mortality is nearly0.36%in our country. With the increasing levels of the treatment, survival time ofpatients is extending gradually. However, Cardiovascular events is the [...]
Background：The aging of the society brought great problems to our country and community,modern lifestyles and eating habits made the atherosclerosis risk factor prevalentwidely. The incidence of ischemic cardiovascular and cerebrovascular disease isincreasing year by year, accounting for the leading cause of death and disabilityworldwide, especially in China. Intracranial arterial stenosis has been considered oneof the [...]
High incidence of cerebrovascular disease, with high mortality and morbidity has be-come a hot, difficulty and focus of medical research. In recent years, the etiology, the patho-genesis and prevention research of cerebrovascular disease has made many achieve-ments. The study results showed that: hypertension, diabetes, obesity, abnormal lipid meta-bolism, arterial atherosclerosis are important risk factors of [...]
Cardiovascular and cerebrovascular diseases have become one of themajor causes of human death and disability. Early studies show that thedeterminants of cardiovascular and cerebrovascular diseases are the arteriallumen stenosis or spasm caused by the distal tissue and organ ischemia orinfarction. However, the recent study found that it is the organizationalcharacteristics of carotid atherosclerotic plaque and [...]
ObjectiveWe regard intima-media thicknes (IMT) and ankle-berahcial index(ABI) as parameters to investigate the relationship between the risk factors of atherosclerosis and type2diabetes(T2DM) with non-alcoholic fatty liver disease(NAFLD).MethodsOne hundred and six type2diabetic patients were divided into two groups (NAFLD Group,n=66and non-NAFLD group,n=40) by liver ultrasound and laboratory exam certificates. Carotid artery intima-media thickness (IMT) were measured [...]
ObjectiveAtherosclerosis(AS)is a major cardiovascular disease pathology. ASis mediated by a variety of inflammatory mediators, which is the injuryperiod of a variety of chronic inflammatory response on arterial wall.This suggests that inhibition of AS is the useful strategy which canprevent the inflammation reaction of cardiovascular disease. Diabetes andAS are closely related, AS of diabetic patients occur [...]
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