Researching backgroundBringmann found 1-Trichloromethyl-1,2,3,4-Tetrahydro-Carboline (TaClo) in 1995.TaClo is the metabolic product of TCE in human body.In the early 20th century, TCE was used as insect repellents, narcotics and abortion agent for a long time, while in the industry as a solvent, cleaning agent widely used until now. In recent years,it was found that long exposure [...]
Background:Multiple myeloma (MM), a B-cell malignancy characterized by proliferation of monoclonal plasma cell in bone marrow, leading to osteolytic bone destruction and impaired hematopoiesis, is an incurable cancer. Despite newer effective agents such as bortezomib, lenalidomide, and thalidomide are changing the therapy of multiple myeloma patients, there is still no cure at present, and multiple [...]
ObjectiveA lot of reasearches have reported that epidermal growth factor receptor (EGFR) and Cyclooxy-genase-2(COX-2) is expressed frequently in non-small cell lung carcinoma (NSCLC), most likely to contribute to the biological characteristics of NSCLC, including development、invasion and metastasis. This study was to determine the interaction of Erlotinib and Celecoxib against human lung cancer A549 cell and [...]
Pancreatic adenocarcinoma is one of the most deadly forms of cancer. The incidence rate of pancreatic cancer is 1% to 3% in human tumors,8% to 10% in gastrointestinal tumors. It is a fast developing disease and is difficult to detect and diagnose. Currently, surgery offers the best possibility for survival, but at time of diagnosis, [...]
Heat shock proteins (Hsps) have been shown to render cardioprotection from ischemic injury; however, little is known about the role of a newly discovered member of Hsp70 family, HSPA12B, which is predominantly expressed in endothelial cells, in cardioprotection against ischemic injury. We recently reported that overexpression of HSPA12B attenuates endotoxemia-induced cardiac inflammatory response. To investigate [...]
Objective:To assess the roles of chloride channels in apoptosis induced by disulfiram/copper in human acute lymphoblastic leukemia Molt4 cells.Methods:The whole-cell patch clamp technique was used to record volume-activated chloride currents. Volume changes of live cells were detected by the time-lapse imaging techniques. The permeability of the cell membrane and nuclear changes were evaluated by Hoechst [...]
Objective Gliomas are the most common type of intracranial tumors, which account for about 50% of all the primary brain tumors.Because of their infiltrating and scalable growth,the tumor tissues often have no clear border with surrounding normal brain tissues.So surgery is hard to eradicate the tumor.What’s more,the glioma cells are not sensitive to traditional radiotherapy [...]
Objective:In this study, we observed the changes of cell proliferation, serum ALT and TNF-a, the abnormal expression of Caspase-3 and Bax protein, pathological changes of liver tissue injured by ethanol. To study the protective effect of grape procyanidins on the liver cell injured by ethanol in vitro and vivoMethod:1 In vitro experiment:The mouse liver homogenate [...]
Hello,My name is Jack,Ph.D. Supervisor, Welcome to My WebSite