Objective: Explore the role of nutritional obesity,which effects on adolescent malerats testicular germ cell apoptosis pathway of Fas / Fas-L system.Method: Select 24, animal rating of SPF Wistar healthy male rats which age are of 3weeks , randomizedly divided into two groups, namely the control and experimentalgroups, each group have 12 rats. Control mice fed [...]
Objective1. To study the expression of the XIAP, caspase-9 and TUNEL-positive cells in Brain ofepilepticus rat;2. To explore the influence and its possible mechanism of the fasudil hydrochloride tohippocampal neuronal of the rats with status epilepticus apoptosis.MethodsWe selected 54 healthy adult male Wistar rats for the following study:1. GroupingAll subjects were randomly divided into three [...]
Objective:Hepatocellular carcinoma (HCC) is a common malignancy tumor, and its mo rbidity and mortality in our malignant tumors accounted for the front position, which is a serious threat to people’s health and life. It is still lack of efficacy, fewer side effect s of treatment of HCC drugs in clinical. Chinese medicine Xiaoaiping fluid (XAP) [...]
Objective: To investigate the effect of docetaxel on nuclear factor-κB activation in humangastric cancer line SGC-7901 after docetaxel stimulation, and to observe the effect of NF-κBinhibition by Pyrrolidine-dithiocarbamate (PDTC) on docetaxel-induced apoptosis of SGC-7901.Methods: SGC-7901 cells were stimulated by different concentrations of docetaxel、PDTC orPDTC combined with Docetaxel in different groups.The Proliferation inhibitions of SGC-7901were evaluated [...]
Objective:To investigate the effect of Egr-1(Early growth response-1)and TNF-a(Tumour Necrosis Factor-a)on the pathogenesis of lichen planus.Methodsr TUNEL was used to detect the apoptotic cells,andthe immunchistochemical technique was used to test the expression of Egr-1and TNF-a in30LP lesions and30normal skins.Results:Compared to the control,the number of apoptotic cells was significantly incresaed in the ketatinocytes and infiltrating lymphocytes [...]
ObjectiveTo explore the effect of captopril on ventilator induced lung injury(VILI) byobserving the relationship between apoptosis and angiotensin II(AngⅡ)in lungs ofrats with high tidal volume ventilation.MethodsThirty male wistar rats were randomly divided into three groups: control group，high tidal volume ventilation(H-VT) group,captopril pretreatment(CAP)group. Lungpathological changes were observed by macroscopy.The lung ALI scores、wet/dryweight ratio and the levels [...]
Objective: Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the mostcommon neonatal diseases, and it is one of major reasons caused neonatal acute death andchronic nervous system damage, and there is no effective treatment at present. Researchhas shown that inhibition of HIF-1α (hypoxia-inducible factor-1alpha) expression aftercerebral ischemia in adult animal models produced neuroprotective effects[3,4]. Thisexperiment give [...]
Objective:To investigate the effects of adiponectin on oxidative stress and apoptosis in Retinal pigment epithelium cultured with high glucose.Methods:The cells were divided into three groups:the normal glucose group, high glucose group and high glucose plus adiponectin group. After culture for24h,48h,72h Oxidative stress was evaluated by detecting levels of MDA and SOD in the supernatant of [...]
Objective To investigate the expression of PCNA, Caspase-3 and Bcl-2 in glomerulus ofdifferent pathological type of IgA nephropathy (IgAN), and preliminary discuss the significanceof the expression of Caspase-3 and Bcl-2 in different type of IgAN. Analyzes the relationshipbetween clinical index and PCNA, Caspase-3, Bcl-2. Further to offer the theory supports aboutapoptosis of the different pathological [...]
ObjectiveTo invetigate the Effects of Etomidate postconditioning on apoptosis and expression of Fas/Fasl in rats following ischemia-reperfusion.Methods40Wistar rats were randomly devided into5groups:the sham group(SH n=8),the ischemi reperfueion group(IR n=8),and three postconditioning groups of ETO(El,E2,E3).in group IR and group ETO(E1,E2,E3)the rats wre subjected to ischemia by clipping of bilateral common carotid arteries.group SH only exposuring bilateral [...]
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