Objective:Isoliquiritigenin (ISL),a simple chalcone-type flavonoid, which is derived from licorice compounds and mainly present in roots of licorice and many other plants, foods, beverages and tobacco.It has been reported to possess a wide range of potent biological and pharmacological activities including anti-oxidative, anti-tumor, anti-aging, anti-inflammatory, anti-diabetic activities and so on. However, the angiogenic effects of [...]
Corydalis Ochotensis Turcz which belongs to the Papaveraceae is always distributed inthe shadow of woods, along the rivers or rocks and deforested regions. In China, it can befound in Liaoning, Jilin, and Heilongjiang province. This herb can be wholly used on sorehurts, dysentery, phthisis, hemoptysis and so on. Generally speaking, there are fewresearches on this [...]
At present, some nitrogen mustard antitumor drugs are used in the clinical, such as cyclophosphamide, ifosfamide, formylmerphalan tablets, they are widely used in clinical, but the lack of targeting, serious side effects and other shortcomings severely limit nitrogen mustard class of drugs widely used. Now the research and development about Nitrogen mustard antitumor compounds are [...]
Objectives：To Design and explore the synthesis of3-bromopyruvic acid prodrug activated byFAP-alpha，in the purpose of finding antitumor prodrug with the advantages of better targeting,higher activity and better bioavailability.Methods:1. Z-Gly-Pro-NH2was synthesized from Z-Gly-OH and L-Pro-NH2. Then it reacted withpyruvic acid followed bromination. The targeted compound had thought to be synthesizedtherefore; Z-Gly-Pro-OtBu was synthesized from Z-Gly-OH and L-Pro-OtBu. [...]
Dihydromyricetin is the effective active ingredient of Ampelopsis grossedentata, possesses various pharmacological action,such as antibiotic action,antioxidation,antithrombotic,protecting liver,regulators blood sugar,regulators blood lipids and anticancer.DMY has already drawn people’s attention. In order to further improve the efficacy and application scope,People has modified the chemical constitution of DMY,which has become the focus of present research. According to prodrug [...]
Background and objectThe antitumor preparation Xian Ci Dan (XCD for short), which is according to the basic theory of Traditional Chinese Medicine and efficacious prescriptions in clinic, is designed by some Chinese Medicine hospital in Guangzhou. It showed significant efficacy towards lung cancer, gastric cancer, liver cancer, nasopharyngeal carcinoma and so on, given administrated alone [...]
1.Study on antioxidant activity of the bee pollen of Brassica napus L.Bee pollen of Brassica napus L. has a broad bioactivities, including enhancing body immunity, delaying consenescence, maintaining the digestive system, and preventing prostate degeneration. It is attributed partly to the antioxidants contained therein. In this paper the antioxidant activity of different fractions of bee [...]
For cancer therapy, optimization of carrier features is necessary to effectively deliver the targeting agents to tumor sites. Biodegradable poly(ether-anhydrides) micelles with spherical (S), rod-like (R) and filamentous (F) shapes are fabricated.Their size and morphology are characterized by Zetasizer, Atomic force microscope (AFM) and Transmission electron microscope (TEM).The doxorubicin hydrochloride (DOX) was used as the [...]
Buckwheat is of high nutritional values and powerful healthy functions. It is known as the most popular green food. In recent years, some researchs had shown that the main active ingredients of buckwheat, Such as trypsin inhibitor and flavonoids, can cut down blood cholesterol, suppress lipopexia, restrain cancer of colon and gallstones, improve constipation, anti-aging, [...]
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