Objective : To compare the separate and combined effects of active carbon absorption andepithelial curettage in corneal alkaliburned rabbits.Methods : 24 adult rabbits were randomly divided into 4 groups,6 rabbits each group.A: controlgroup.B: active carbon absorption group.C: epithelial curettage group.D: combined therapygroup.Then established the model of alkaliburned corneas in each right eye.After absorption andcurettage,same regular [...]
Corneal is an important transparent tissue occupying the anterior pole of the globe. The injury because of mechanical injury, operation and chemical burn are very common in superficial injury of eye. The processes of wound healing and scarring are essential means by which the body maintains its structural integrity, but tissue repair in and around [...]
Objective:The different expression of nuclear factor Kappa B in rat lens epithelial cells was investigated after alkali burn in the rat eye surface between experimental group and contral group.Inhibitor of nuclear factor was used in experimental group and normal sodium was used in control group.Methods:Ocular surface alkali burn model was made in rat.Inhibitor of nuclear [...]
Objective To investigate effect of peroxisome proliferator-activated receptor gamma ligand(Pioglitazone) on IL-1a and IL-6 in alkali-burned corneas of rats.Methods 40 SPF level Wistar rats were divided into 5 groups randomly,one of these groups as a normal control group(Ⅰgroup,n = 8),and the remaining 32 rats were established corneal alkali-burn models in their right eyes.After corneal alkali-bum [...]
ObjectiveCorneal neovascularization,(CNV) was common in corneal diseases,which was caused by many reasons.It is a major complication of corneal injury from chemical burns from accidental exposure to solvents,detergents and alkali,and of corneal infections including bacterial,Chlamydial,parasitic and viral infections Corneal vascularisation is a potentially devastating occurrence that can cause blindness. Treatment of neovascularisation of the cornea remains [...]
Background:The course of corneal repair after alkali burn is often accompanied by the occurrence of neovascularization. Corneal vascularization which often leads to loss of corneal transparency is not only an important cause of blindness,but is also a risk factor of rejection after keratoplasty. It has been found that many cytokines involved in the formation of [...]
Objective:we have observing the clinical conditions of clipped PMMA (polymethyl methacrylate) keratoprosthesis(K-pro) by ourselves implanted into alkali burned rabbit corneas and discuss of the study, including Kpro designs,operative methods,compalications;To abserve the biological compatibility about the PMMA and silicone materials deeperly. Methods:The first,it is would be made 5 cases that the alkali burned rabbit corneal leucoma [...]
Objective: To explore the difference of the experimental rabbit corneal neovascularization by suture-induced and alkali burn.Method: All animals(n=75)were randomly divided into three groups, normal control, consisting of 10 eyes(5 rabbits) ,the others each consisting of 35 eyes (35 Rabbits) . Rabbits corneal suture-induced and alkali burn models were established by routine methods. Biomicroscopic features including [...]
Abstract Objective:To established the animal model of ocular alkali burns in SD rats, and observed the expression of the P63 and proliferating cell nuclear antigen on the corneal limbus.Present study was to discuss the effect of corneal limbal stem cell(LSCs) proliferation by transplantation of amniotic membrane after alkali burn.Methods:A total of 40 healthy SD rats [...]
Objective:To evaluate the inhibition effect of bevacizumab on rat cor-neal Neovascularization model.Methods:Twenty-eight wistar female rat, were randomly divided into two grous:Control group and Treatment group, each include 14 rats. Twenty-eight rats were used to make corneal alkali-burned model by 1 mol/L NaOH. Control group was given 0.25% of Chloramphenicol eye drops, Experimental group was given [...]
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