Background and Objective:Alcoholic liver disease (ALD) is a chronic liver disease induced by long-term alcohol abuse, the incidence of which is pretty high in Western Countries. Recently, with development of economy, improvement of living level and modification of life style, the number of alcoholic is increasing, and the incidence of ALD assumes year by year [...]
Objective Alcoholic liver disease (ALD) pathogenesis is unclear, the literature shows that cytokine’s role in ALD has been attached To observe the expression and significance of TNF-α,IL-6,NF-κBin alcoholic liver disease (ALD) patients. Preliminary understanding of cytokines in ALD role and study the apoptosis in the ALD role.Methods By enzyme-linked immunosorbent assay (ELISA) detected 54 cases [...]
Objective: Alcoholic liver disease (ALD) is a toxic liver disease caused by alcohol abuse. Histopathological features of ALD include mild alcoholic injury, alcoholic fatty liver, alco- holic hepatitis, alcoholic hepatic fibrosis and cirrhosis. The pathogenesis of ALD which remains obscure as yet is very complicated. Endoplasmic reticulum (ER) stress can induce hepatocyte apoptosis which may [...]
Fucoidan isolated from sea cucumber(SC-FUC) is a sulfated polysaccharide, and mainly exist in the body wall of sea cucumber. But at present the researches about SC-FUC are very few. The present study investigated the prevention Alcoholic Liver Disease of SC-FUC. In this study, the effects and mechanisms of preventive and therapeutic Alcoholic Liver Disease(ALD).The mice [...]
Fucoidan isolated from sea cucumber(SC-FUC) is a sulfated polysaccharide, and mainly exist in the body wall of sea cucumber. But at present the researches about SC-FUC are very few. The present study investigated the prevention Alcoholic Liver Disease of SC-FUC. In this study, the effects and mechanisms of preventive and therapeutic Alcoholic Liver Disease(ALD).The mice [...]
Objective: Through the treatment of eliminate wetness and disintoxication in Alcoholic Liver Disease, we try to find a new way of therapy in this disease.Methods: In the clinical observation,72 patients are divided into two groups randomly.The treatment group uses traditional Chinese medicine following the principle of eliminate Wetness and Disintoxication,the control group accepts the treatment [...]
Purpose:To establish the models of the different concentration of alcohol-induced steatosis in L-02 liver cells. To explore the effect of different ethanol concentration on the lipogenesis and the releasing dose of alanine amino transferase(ALT), aspartate amino transferase(AST) of L-02 liver cells, and to investigate whether hovenia dulcis thumb extracted liquid has therapeutical effect on the [...]
Objectives:To observe MuLiTang’s treatment effect on syndrome of Chinese medicine and AST,ALT,GGT and AST,ALT,GGT in Mild-to-moderate AH of spleen deficiency. To provide necessary scientific basis on further research and clinical application of MuLiTang.Methods:60 cases of AH of spleen deficiency were randomized into two groups.30 cases of experimental group take MuLiTang,while 30 cases of control group [...]
Objective:To observe the clinical effect of method of HXHY on ALD.Methods:60 pationts with ALD were divided randomly into two groups:treatment group of 30cases: treated with Diammonium Glycyrrhizinate Capsules and Fufang Yiganling Pian,and decection of HXHY was in addition. Control group of 30cases: treated with only Diammonium Glycyrrhizinate Capsules and Fufang Yiganling Pian .The clinical therapeutic [...]
Purpose: According to the parenchymal liver cells isolation, purification and culture in vitro, analyzing the growth of primary hepatocyte, to study the Hepatocytes Toxicity of Rat and variation of intracellular dissociative Ca2+ induced by acetaldehyde, and the interventional effect of Ca2+ chelator, approach to the injury pathogenesis of liver cells induced by acetaldehyde and the [...]
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