Objective: To explore the effect of perinatal hypoglycemia on brain injury in preterm infants with acidosis.Methods: One hundred and fifty-three cases of preterm infants with acidosis were analyzed retrospectively . Short term brain injury includes death result from severe encephalopathy and moderate to severe encephalopathy with or without seizures . Hypoglycemia was defined as an [...]
Background and objective: It is the important problem to conclude postmortem interval (PMI) for the practice of forensic science , although how to exactly deduce PMI is challenging.The relation between the change of ion concentration of Vitreous humor and PMI after death, attracts more and more attention. But the influence of different factors resulting in [...]
Objective (1)To observe the effects of prolonged transient acidosis on coronary flow and the pH of coronary effluent in aged rat heart after reperfusion injury.(2)To investigate the effects of acidic reperfusion on isolated rat heart against ischemia reperfusion injury and the role of PI3K signaling pathway in it.MethodsExperiment 1: Twenty-four aged SD rats,which were 18 [...]
Objective: To investigate the effects of different fluids (sodium lactate Ringer’s solution and sodium pyruvate Ringer’s solution) on the survival rates, visceral functions and metabolic acidosis during the resusciation of lethal hemorrhagic shock in rats.Methods: 1.Chose male Sprague-Dawley rats,with the body weight between 280g and 300g.Fixed rats on the operating table with supine position after [...]
Ischemic stroke is a leading cause of death and disability worldwide, and it’s related to a transient or permanent reduction in cerebral blood flow. Many studiesshown that ischemic brain damage is resulted from multiple factors such as changes of neurotransmitters, tissue acidosis, production of free radicals, an ion balance disorder, lipid peroxidation, apoptosis and inflammation. [...]
Objective Angiogenesis is tightly controlled by two counter-balancing systems: angiogenic stimulators such as vascular endothelial growth factor (VEGF) and angiogenic inhibitors such as pigment epithelium-derived factor (PEDF). Hypoxia induces production of VEGF and inhibits generation of PEDF, and causes neovascularization. After onset of hypoxia, glycolytic flux increases, so do lactate and H+. Impairment of vascular [...]
Incidence,mutilation and mortality of ischemic cerebrovascular disease are high. Ischemic cerebrovascular disease,cardiac disease and malignant tumor become three major death causes in human beings.Exploring mechanisms of ischemic neuron injury will help prevention and treatment of ischemic brain injury.Although huge improvement on mechanisms of ischemic brain injury has been made from cytology molecular biology, but no [...]
Ischemic stroke is one of the major causes of human death and disabilities with main parthological mechanism of neuronal injury by ischemia. Acidosis is a common feature of ischemic brain. Accumulation of lactic acid as a byproduct of glycolysis and protons produced by ATP hydrolysis cause extracellular pH reduction during brain ischemia. Acidosis lasts for [...]
pH value is an important physiological indicator of internal environment homeostasis. Under normal conditions, pH values in Peripheral blood, tissues and organs are usually 7.2-7.4. However, in some diseases, such as inflammation, autoimmune disease and tumors, the values of extracellular pH are much lower than that of normal tissues, and low pH values play an [...]
Normally, the pH value of the organ and tissues of our body ranges from 7.2 to 7.4. In many pathological conditions, peripheral organizations typically present acidification, for example acute asthma, tumor, inflammation, autoimmune disease, etc. So, microenvironment acidification plays an important role in immune system.As one of the most important groups of immune cells, macrophages [...]
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