Objective: With organotin becoming widely applied as one of the lead-free stabilizer substitute, TMT, the byproduct of organotin production, has therefor been widely exists in production and people’s daily life; acute poisoning incident caused by TMT was common, the harmful effects of which has become more and more serious. Previous study showed that TMT exerts [...]

Objective:The objective is to research the expression of WISP1 in the asthmatic model in rats Construction and the expression of it when RTED are stimulated by different kind of inflammatory factors. This paper, which considers Wnt signaling pathway as the research subjects, analyze the relationship of WISP1 and the morbidity of asthma, and on the [...]

Background:With constantly increase of the global prevalence of diabetes, diabetes mellitus has become a frequent and severe public health problem, its unique vascular complications are the major cause of blindness, disability and death. Recently, endothelial dysfunction is well-recognized as a primary contributor in the development of diabetic vascular complication. A large quantity of evidences have [...]

Objective To investigate the in vivo effects of down-regulating the FGF-21 gene expression by shRNA on glucose and lipids metabolism in high fat diet fed ApoE-/- mice (HFD).Methods Male ApoE-/- mice were randomly divided into chow diet (CF) fed group (NF, n=10), CF fed + pAd-shFGF-21 group (NFG, n=9), and HFD fed group (HF, n=10), [...]

Objective: To transfect interference-plasmids to silence the genes of STAT4, STAT6 and CBP, and to observe the interactions between STAT4, STAT6 and CBP, the Jurkat celllines of overexpression of STAT4 and STAT6 are to be constructed.Methods: The plasmids pIRES2-EGFP, pIRES2-EGFP-STAT4 and pIRES2-EGFP-STAT6 which have Neo/Kan gene are transfected into Jurkat cells by DMRIE-C, and then [...]

PartⅠThe efficacy and mechanism to allergic asthmatic mouse with different dose of dermatophagoides farinae vaccine Objective To investigate the efficacy and mechanism to allergic asthma mouse with different dose of dermatophagoides farinae (der f) vaccine.Methods 32 female C57BL/6 mice were randomly divided into 4 groups after setting up the allergic asthma mode with the extract [...]

Objective: To establish an insulin resistance (IR) animal model induced by hypoadiponectinemia in ApoE-/- mice and further to investigate the effects of hypoadiponectinemia on the related genes expressions of glucose-lipid metabolism and to examine the effects of liraglutide on the adiponectin gene inhibition-mediated insulin resistance.Methods: Thirty two ApoE-/- mice fed HFD for 16 weeks were [...]

31. May 2012 · Comments Off · Categories: Endocrine · Tags: , , ,

Objective:Investigate the quality of life survey in children with type 1 diabetes, to evaluate quality of life of children and adolescents with diabetes in Chongqing. Investigate education interventions of children and adolescents with diabetes, to improve their quality of life.Methods:”Children’s Diabetes Camp”had held in our hospital in may 2010 . Diabetes (DM) Patients Quality of [...]

Objective:The main reason of high incidence of cardiac arrhythmias,including ventricular fibrillation and sudden death in diabetic patients, probably attributed to myocardial electrophysiology changes, which be induced by the abnormal activity of cadiocyte ion channel after Diabetes mellitus.The transient outward potassium current (Ito) , as the first repolarizing current of myocardium action potential (MAP),plays an important [...]

Environment is material foundation of human survival and development. However, with the development of modern industry, many toxic artificial organic materials enter human body through various channels, and accumulate in the human body to cause lasting damage to human body. Phthalic acid ester (PAEs) is a global environmental pollutant, which can not only interfere with [...]