Objective:Study the effect and security of the Yishenmigu Decotion on postmenopausal osteoporosis with the deficiency of liver and kidney, forming the foundation for a Decotion of postmenopausal osteoporosis.Methods:60 patients with postmenopausal osteoporosis were randomly divided into the therapeutic group(Yishenmigu Decotion)and control group (Xianlinggubao Capsule),30 cases each group. Compare comprehensive therapeutic effects and bone mineral density (BMD) between two groups, respectively, after 12 weeks,24 weeks. Because treatment fairly long, junior fellow apprentice will observe and summarize after 24 weeks.Results:1. The Yishenmigu Decotion has significant effects in symptom remission, the effective rate of therapeutic group was 83.3%,while the control group’s was 86.7%,there was no statistically significant difference between them(p>0.05). The accumulated points of symptom of traditional Chinese medicine were both statistically significant degraded (p<0.05), but there was no statistically significant difference between this two group (p>0.05).2. Safety analysis:There were no untoward reactions in both therapeutic group and control group in the clinical test after 12 weeks.Conclusions:Yishenmigu Decotion has a constant effect on the patients of postmenopausal osteoporosis in this clinical practice:it can relieve the symptoms and improve physical signs of patients. It is a kind of safe medicine and be worth generalizing to clinical use.