The incidence of Osteoporosis (OP) has increased obviously with the aging ofsociety ,69400000 people over the age of 50 suffering from OP in our country,andOP in postmenopausal women (postmenopausal osteoporosis ,PMOP) account for1/3,which will bring bone pain and fracture for patients and heavy burden for socialand family.Therefore,it has become an urgent need to study the [...]
BackgroundDaunorubicin is an anthracycline antibiotics, as the basic drug of clinic chemotherapyscheme because of its damage DNA, inhibit the topological isomerase Ⅱ (Topo Ⅱ) role.Butwith strong side effects, and happened resistance and recurrence easyly, make its applicationsubject to limit, the mechanisms of resistance may is NF-kB signal path abnormal activation andcause cells resistant gene expression [...]
Objective:To investigate atorvastatin, pioglitazone and two drugs in combination on ischemia-reperfusion myocardial protective effects and the possible mechanism.Methods:The experimental animals were divided into A, B two groups:healthy male SD rats weighing (200±30) g, were randomly divided into A and B, the two groups.Group A was normal control group, without any treatment.Group B for the diabetic [...]
Objective: Investigate the effect of bortezomib and with the combination ofMTX on the T-cell acute lymphoblastic leukemia (T-ALL) proliferation. Discuss theexpress of Notch1pathway signal in the T-ALL cell line (CCRF-CEM) by usingbortezomib, in order to search a new way in the T-ALL treatment.Methods:1. Cell culture. Human T-ALL cell line CCRF-CEM was cultured inRPMI medium1640.2. Cell [...]
The restoration of blood flow after ischemia can also cause further tissue demage anddysfunction in some cases which we called it reperfusion injury.ObjectiveTo establish the cerebral ischemia reperfusion injury model of rats. To observe the effects ofEtomidate postconditioning on the brain tissue malondialdehyde(MDA)concentration andsuperoxide dismutase(SOD)activity in rats induced by cerebral ischemia-reperfusion(CIR) so asto investigate cerebral [...]
ObjectiveTo study the influence of the multiplication of cartilage cells,the expression of collagen Ⅱ and GAG content on NS and HA.To study the influence of the multiplication ofcartilage cells,the expression of collagen Ⅱ and GAG content on TGF-β1.To study theinfluence of the multiplication of cartilage cells,the expression of collagen Ⅱ and GAGcontent on HA as [...]
The establishment of essential drug policy of China’s medical and health system reformis an important content, but also to reduce the price of drugs, solve people “sees a doctordifficult, expensive” is one of the most important measures. The essential drugs is social allresidents in the medical process is the most important, the most basic, essential [...]
The science in nanometer scale, which is jusaposed the information science and the bioscience, is one of the three most important research fields in the 21 century. In the past 30 years, the nanoscience had a rapid development. The application and basic research of nanomaterials in many medicine-related fields has also made significant progress. However, [...]
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