Objective:In this study, we explored the therapeutic effect of Fasudil at different stages of experimental autoimmune encephalomyelitis, and studied possible mechanisms of the action, providing experimental basis for further clinical treatment of multiple sclerosis (MS).Methods:Chronic EAE model was established in female C57BL/6mice immunized with MOG35-55. After immunization,42mice were randomly divided into EAE group, Fasudil early [...]
Objective To investigate whether CD40gene (-1C/T) single nucleotide polymorphism(SNP) is associated with the stability of carotid artery plaque, while analyse the association CD40gene (-1C/T) single nucleotide polymorphism(SNP) and occurrence of ischemic cerebrovascular disease..Methods:170patients with acute ischemic cerebrovascular disease were selected as cerebral infarction group,all subjects were detected the plaque echogenicity and morphology were evaluated bilaterally [...]
Objective1. To study the expression of the XIAP, caspase-9 and TUNEL-positive cells in Brain ofepilepticus rat;2. To explore the influence and its possible mechanism of the fasudil hydrochloride tohippocampal neuronal of the rats with status epilepticus apoptosis.MethodsWe selected 54 healthy adult male Wistar rats for the following study:1. GroupingAll subjects were randomly divided into three [...]
Objective:Thorough the determination of serum cytokines IL-6, IL-17levels in Firstdepressive disorder patients, and its correlation with the first episode of majordepressive disorder, to investigate the function of cytokine IL-6, IL-17in thepathogenesis of depressive disorder provide a scientific basis for the diagnosis andtreatment of major depressive disorder.Methods:Using Case-control study, and the enrollment exclusion criteria to strictly [...]
Objective To investigate the effects of recombinant human granulocyte colony-stimulating factor(rhG-CSF) on the expression of nuclear factor-kappaB(NF-ΚB) and induciable nitricoxide synthase(iNOS) in rats with focal cerebral ischemia/reperfusion. To explore the anti-inflammatory mechanisms of rhG-CSF, and to provide a new theoretical basis for clinical application.Methods Thirty-six male Sprague-Dawley rats were randomly divided into the sham-operated group, [...]
Background:Clinical isolated syndrome(CIS), it is to point that acute or subacute single attack in the central nervous system except the other diseases, and last time more than24hours, the develop of the time and the progress of the space are not accord with multiple sclerosis(MS) or neuromyelitis optica(NMO) diagnostic criteria. CIS mainly includes optic neuritis(ON), isolated [...]
Objectives:Through the analysis of intracranial aneurysms in 3D TOF-MRA, CE-MRA and DSA onimaging findings, evaluate the advantages and disadvantages of 3D TOF-of MRA, theCE-MRAand DSA on the diagnosis of intracranial aneurysms. Explore Application value of 3DTOF-of MRA, the CE-MRA and DSA in the clinical diagnosis of intracranial aneurysms.Methods:Collecting 38 cases From March 2011 to January [...]
The causes of dizziness is complexed, and anxiety, depression and other mood disorders inwhich occupies an important position. Studies suggest that central serotonergic system the keyfactors in etiology anxiety disorders and depression. So the genes that code for proterns involvedin regulation of serotonin sunthesis, release, uptake and metabolism, are major candidate genesin association studies of [...]
Background Clinically isolated syndrome (CIS) is the initial demyetinating event in the central nervous system and often present as optic neuritis brainstem or spartial-cord syndromes. CIS evelve into optic nerve myelitis (NMO) or Multiple sclerosis(MS). NMO, also known as Devic’s disease or Devic’s syndrome, is an autoimmune, inflammatory disorder in which a person’s own immune [...]
Hello,My name is Jack,Ph.D. Supervisor, Welcome to My WebSite