Background:Hepatolenticular degeneration (HLD), also called Wilson disease(WD), is an autosomal recessively inherited disorder of copper metabolism. The main clinical presentations are lower serum Cu and ceruloplasmin (CP) levels, cirrhosis, gradually serious extraparamidal neurological symptoms, Kayser-Fleischer ring (K-F ring) and psychiatric symptoms. WD gene mutations were highly genetic heterogeneity, the hot regions of mutations and frequent [...]
ObjectiveChina has been regarded as one of the countries suffering seriously from the prevalence of endemic flurosis which becomes a regional disease widely spreading around the world.The research concerning the influence of the combination of selenium and vitamin C on endemic fluorosis has not yet been reported. Based on the individual effect of selenium and [...]
Objective To understand the psychological status of the patients with CHD in community hospital, the environmental factors of depression/anxiety were surveyed, and psychological intervention was evaluated in coronary artery disease associated with depression/anxiety.Methods Randomly selected 60 patients with coronary heart disease who filled the achieves completely from four neighborhoods in Qingdao to form the study [...]
Objective:Through observing the number change of CD3+Tcell, CD4+Tcell, CD8+Tcell, the expressions of CD4+HLA-DR+, CD8+HLA-DR+and the secretion of CD8+ Granzyme-B+ as well as the Treg cell quantity change in tubercular pleurisy patients’hydrothorax and peripheral blood to study the pattern change of a BTcell subsets and immunological pathogenesis in the patients who with Tuberculous pleurisy,then analyzeing the [...]
Objective:To study the changes of immunologic function in patients with chronic obstructive pulmonary disease (COPD) and the intervention by BCG polysaccharides nucleic acid.Methods:We selected 90 subjects with COPD and divided them into two group:COPD group of acute exacerbation (n=30), COPD group of remission (n=60). At the same time, 60 healthy subjects were chosen as control [...]
Objectives:To investigate the peripheral blood cell CD34+ ratio and evaluate the coronary lesion and clinical condition by the Syntax-score and the EuroScore systems in CHD patients complicating DM, and then reveal the relationship between the clinical conditions and the result of coronary angiography, and to try to find its mechanism.Methods:96 consecutive patients who recieved coronary [...]
Objective To study the expression of stromal cells-derived factor land CXC chemokine receptor 4 (SDF-1/CXCR4) in the acute infarct myocardium in rat after implanation of hypoxic preconditioning bone marrow mesenchymal stem cells (HPMSCs).Methods MSCs were isolated and purified for culture in vitro and serial passage by the attachment culture method. The morphological changes of the [...]
Objective:The present study is designed to investigate the effects of losartan on the activity and expression of Na+, K+-ATPase in the proximal tubules epithelial cells of spontaneously hypertensive rats(SHR), and to understand the relationship between the effects above-mentioned and that of depression.Methods:12 male SHRs 10 weeks after birth (body weight:140±17g) were randomly divided into intragastric [...]
Purpose:The subject of clinical effects to be adopted, evaluation of traditional Chinese medicine syndromes, liver enzymes, jaundice, weightChanges in abdominal girth decrease, liver fibrosis, and coagulation function were to observe the change in Modified wide-Yu Tang and western medicine treatment of ascites in liver cirrhosis the clinical efficacy, and further explore the pathogenesis of cirrhosis [...]
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