Objective: To establish a tibial cancer pain model with MADB-106 mammary gland carcinoma cell line and to conduct therapeutic research through the behavior pain, x-ray, histological observation of the model.Methods: A rat model of bone cancer pain was established by intra-tibial inoculations of MADB-106 ratmammary gland carcinoma cells in Sprague-Dawley rats. Spontaneous pain was assessed [...]
Objective:To establish rabbit animal model of sciatic nerve trunk injection injury; To reveal effect of sciatic injection injury on enzymohistochemistry of skeletal muscle in rabbit’s legs; To explore the laws of enzymohistochemistry changes; and discuss the mechanism of skeletal muscle atrophy preliminarily.Method:45 adult healthy rabbit were used,2.50±0.50 kg; they were randomized into the normal group, [...]
Part one:Establishment of the seizures induced by electrical stimulation of rat dura mater modelObjective:To determine the convulsion threshold by electrical stimulation of rat cerebral dura mater and observed the changes in behavior of the rats after the stimulations.Methods:The 30 rats were randomly divided into operation group, intervention group and sham surgery group. In this study [...]
[Object] To probe into methods of observing behavioral indexes of experimental minipigs in the basic research on traditional Chinese medicine (TCM).[Medthods] In large animal house, the special cages and electronic surveillance system were adopted in this series to observe and record the changes in the behavior of minipigs before and after pathological modeling.[Results] The two [...]
The lack of proper animal models is still a major obstacle for AIDS research. Although nonhuman primate (NHP) is on the top list of consideration an ideal model in many aspects, the innate anti-retroviral restriction factors of NHP prevent the direct use of monkeys as animal models for HIV-1 infection. Recent studies have shown that [...]
Atherosclerosis (atherosclerosis, AS) can lead to cardiovascular, cerebrovascular diseases, so it is serious disease threaten to human health. With the development of society and increasing competition of stress. It impact human health more and more. Therefore, the establishment of an ideal model of induction of oral tolerance on anti-atherosclerosis is significant. This study is based [...]
The interferons represent proteins with antiviral activity that are secreted from cells in response to a variety of stimuli. Interferon can induce cell to produce some proteins which have activities like enzyme. By those proteins interferon can restrain virus coping and damage virus. Interferon also has antitumor activities and immune-regulated function. In general, exposure of [...]
Idiopathic pulmonary fibrosis (IPF) is a chronic and often fatal pulmonary disorder. Continued fibrosis leads to loss of lung function and ultimately death, Numerous factors have been implicated in this process, the molecular mechanisms of IPF are still controversial and elusive, but there are some signs show that fibroblast, proliferation, extracellular matrix deposition, and progressive [...]
Diabetes has become the third largest non-communicable diseases, second only to cardiovascular disease and cancer, to find a feasible method of treatment of diabetes is of great significance. It is the global hygine issue. Dietary fiber has unique physical and chemical properties and other physiological functions, have been reported with hypoglycemic effects. Possible mechanisms include [...]
Objective:The model of anterior segment ischemia(ASI) in rabbits after multi-rectus tenotomy in both eyes was established.To investigate the expression of VEGF in expremental anterior segment inchemia in rabbits, and inquire the contact with each other. And suramin has the inhibitory effect on VEGF. Then provide the therapeutical thinking for ASI.Materials and methods:54 purebred male Japanese [...]
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