ObjectivesDrug recombinant human parathyroid hormone （1-34） intervention on changes ininsulin-like growth factor1（IGF-1） the impact of their bone mineral density, insulin-like growthfactor1（IGF-1） in rats fracturestudies provide a reference.MethodsThe choice of a5-month-old female SD rats of90randomly selected5measured bonedensity, and the rest divided into sham group, control group and the recombinant humanparathyroid hormone （1-34） treatment group. Sham group [...]
Objective: Explore the role of nutritional obesity,which effects on adolescent malerats testicular germ cell apoptosis pathway of Fas / Fas-L system.Method: Select 24, animal rating of SPF Wistar healthy male rats which age are of 3weeks , randomizedly divided into two groups, namely the control and experimentalgroups, each group have 12 rats. Control mice fed [...]
Objectives:This study was aimed to explore the difference of glucose situation between the normalsubjects and DM patients through continuous glucose monitoring; The article was designed toexplore the impact of chronic blood glucose fluctuations on development of coronary arterydisease in patients with type 2 DM through the study of different glucose fluctuations betweenType 2 DM with [...]
Objective::To observe the effect of exendin-4on the expression of transforming growth factor Beta-1and membrane-type matrixmetalloprotein ase-1in the renal tissues of diabetic nephropathy rats.METHODS:1. model of diabetic nephropathy rats had been established by high-fat and high-suger diet and intraperitoneal injection of a low dose of strptozotocin.the rats were randomly divided into3groups:diabetic nephropathy group, lower dose of [...]
Objective:The aim of this investigation is to exam the the expression of PPARy2mRNA under the effect of glargine insulin, detemir insulin and human insulin in3T3-L1adipocytes and possible mechanisms.Methods:1. Culturing3T3-L1preadipocytes in vitro is to differentiate it into mature adipocytes. There were4major sample groups based on the different types of induction medium containing insulin. They are glargine [...]
Objective:To determine the changes of P wave dispersion (PWD) in patients with hyperthyroidism, and to compare the short-term effect of propranolol and propylthiouracil in treatment of PWD.Methods:Thirty patients with initial hyperthyroidism were randomly divided into a propylthiouracil group and a propranolol group, and were given propylthiouracil tablets100mg,3times/d, oral and propranolol tablets10mg,3times/d, oral for three weeks, [...]
Objective To investigate the expressions of peripheral blood mononuclear cells(PBMCs) interleukin-23p19mRNA and plasma interleukin-23in patients with type2diabetes mellitus(T2DM) before and after therapy, further explore the relationship between interleukin-23and T2DM during the occurrence and development.Methods The study applied retrospective case-control study,the case group selected58patients with T2DM, the fasting plasma glucose level in selected grouping objects,28cases with [...]
Objective:To compare the efficacy and safety of domestic rosuvastatin and domestic atorvastatin in patients with hyperlipidemia.Methods:123patients with hyperlipidemia were randomized into A group、 B group、 C group. Forty-four patients in A group was treated with domestic rosuvastatin5mg· dd1, Forty patients in B group was treated with domestic atorvastatin10mg· dd1, Thirty-nine patients in C group was [...]
Objective：To probe the protective action of simvastatin on kidney and its influence onexpressions of TLR4 and MCP-1 in kidney tissue of type 1 diabetic rats.Methods：54 male Wistar rats, weight 180-220g, were provided by the Animal ExperimentalCenter of Shanxi Medical University. All the rats was clean. The rats were randomly divided intothree groups: normal control group [...]
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