Objective:To observe the effects of anti-gout capsule on expression of the MMP-1 and TNF-a in articular cartilage tissues of acute gouty arthritis rats.Method:The fifty male SD rates were randomized to the control, model, positive control(cochicine 0.8mg/kg), and anti-gout capsule low dose(0.3g/kg), high dose group(1.2g/kg). Besides control group, the gout model was made in other groups [...]
[Objectives]In this study, we examined the effect of soy isoflavone, a class of plant estrogens (phytoestrogens) found predominantly in legumes, on prevention of osteoporosis using an adult ovariectomized (OVX) rat model.[Methods]The 1303-mo-old female Sprague-Dawley rats were randomly divided into thirteen groups:normal control group (n=10 rats) received only placebo were sacrificed by 24 weeks, and ovariectomized [...]
Objective:To investigate the clinical significance about bone metabolic markers in the diagnosis and treament to old patients with osteoporotic fractures, to research its correlation with pathological histology and BMD changes, and to find a new reasonable treatment for old patients with osteoporotic fractures.Methods:1.100 old patients with osteoporosis(60 males and 40 females) were selected in orthopedics [...]
Background and Objective Diadetic nephropathy in our country has an important position in liver glomerular disease. With the increasing of diabetes incidence,the incidence of diadetic nephropathy increases a lot. Nowadays diadetic nephropathy has become the main causes of the end-stage renal failure. At present there has no specially good effective treatment to diadetic nephropathy, except [...]
BackgroundThe type 2 diabetes mellitus (T2DM) is a result of long-term effects of genetic and environmental factors, and insulin resistance and insulin deficiency are two important mechanisms of the disease. Obesity can affect many parts of the insulin signal pathway, reducing the effects of insulin, reducing insulin sensitivity, leading to abnormal glucose regulation. Long-term high-fat [...]
Objective To investigate the therapeutic effects of rosiglitazone on the level of serum glucagon-like peptide-1(GLP-1).Methods Totally seventy-four patients aged 38-75 years of Type 2 diabetic who need to use insulin and metformin therpy were selected. The body mass index (BMI) was 21.5-29.5kg/m2, and the average BMI was 25.5±2.4kg/m2. Except for severe cardiac insufficiency, liver and [...]
Objective:To observe the changes of blood lipid, glycolated hemoglobin (HbAlc), plasma homocysteine (Hcy) and the carotid artery intima media thickness(IMT) in newly diagnosed patients with type 2 diabetes mellitus(T2DM) before and after one year therapy of metfiormin, and analyse the relationship between IMT and the variables. To explore the role of Hcy and IMT in [...]
ObjecctiveTo investigate the clinical significance of YKL-40 in differential diagnosis of papillary thyroid carcinoma(PTC) and benign nodules through comparing the serum and tissue YKL-40 in all groups.Research design and methods1. Study object:The 40 inpatients with malignant throid nodules(all PTC) and 40 inpatients with benign thyroid nodules(nodular thyroid goiter and thyroid adenoma) were divided into two [...]
Objective:To investigate the effects of UCP2 and its posssible mechanisms in IR induced renal injury of mice by examing the expression of UCP2 mRNA and protein as well as its relationship with MDA.Methods:Twenty-eight male C57/BL6 mouses were divided randomly into normal control、IR1、IR2 and IR3 groups(n=7).All of the mouses were intraperitoneal injectied pentobarbital for anesthesia and [...]
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